目的建立麻仁软胶囊指纹图谱。方法采用Diamonsil C18柱(250 mm×4.6 mm,5μm),流动相为甲醇-0.05%磷酸梯度洗脱,检测波长230 nm,柱温30℃,体积流量1.0 mL/min。测定10批麻仁软胶囊,建立指纹图谱。结果指纹图谱各项参数符合标准,22个共有峰及1个共有峰群,进行了主成分分析。结论建立了麻仁软胶囊指纹图谱,该方法可更全面地控制麻仁软胶囊的质量。

To establish the HPLC fingerprint of Maren Soft Capsula. Methods The HPLC method was used with Diamonsil C₁₈ column (250 mm × 4.6 mm, 5 μm), and a mixture liquid of methanol-0.05% H₃PO₄ as mobile phase in a gradient elution. Detection wavelength was 230 nm, flow rate was 1.0 mL/min, and column temperature was 30 ℃. The HPLC fingerprint was established of 10 batches of Maren Soft Capsula. Results Under the selected spectrum condition, the 10 batches of Maren Soft Capsula showing 22 common peaks and 1 common peak group, principal components analysis was carried out. Conclusion This method is reasonable and reliable to the quality control of Maren Soft Capsula.

“十一五”国家科技支撑计划项目(2006BAI06A01-02);天津市科技创新专项