目的 对消炎镇痛巴布膏剂中的主药丹参透皮特性进行研究，优选消炎镇痛巴布膏剂最佳渗透促进剂。方法 以丹酚酸B和丹参酮II_A为指标性成分，采用Franz扩散池法进行体外透皮吸收实验，用HPLC法测定丹酚酸B和丹参酮II_A在不同促渗剂下的透皮吸收速率和累积透皮渗透量。结果 丹酚酸B和丹参酮II_A在不同的促渗剂下具有不同的透皮吸收量，在氮酮-丙二醇（1∶1）促渗条件下，巴布剂中丹酚酸B和丹参酮II_A透皮吸收速率分别为3.62、1.35 μg/(cm²·h)（大鼠皮肤），24 h累积渗透量分别为88.72、16.12 μg/cm²，分别是不含促渗剂的巴布膏剂透皮吸收速率的6倍和10倍。结论 以氮酮-丙二醇（1∶1）作为渗透促进剂，对水溶性丹酚酸B和脂溶性丹参酮II_A都有较好的促渗作用。

Objective To study the transdermal penetration absorption of Salviae Miltiorrhizae Radix et Rhizoma, the monarch drug in Xiaoyan Zhentong Cataplasm and to optimize the transdermal penetration enhancers of Xiaoyan Zhentong Cataplasm. Methods The Franz diffusion cell was used to study the in vitro permeation behavior, and salvianolic acid B and Tanshinone II_A were chosen as indexes. Samples with different penetration enhancers were assayed by HPLC method to determine the cumulative permeation quantity and permeation rate of salvianolic acid B and Tanshinone II_A. Results When azone - propylene glycol (1 : 1), the permeation rates of salvianolic acid B and Tanshinone II_A through rat skin in vitro were 3.62 and 1.35 μg/(cm²·h), respectively, and the 24 h permeated amounts were 88.72 and 16.12 μg/cm², respectively. Compared with the Xiaoyan Zhentong Cataplasm without penetration enhancers, the permeation rates increased by 6 and 10 times, respectively. Conclusion The combination of Azone - propylene glycol (1 : 1) is an effective penetration enhancer both to water-soluble salvianolic acid B and liposoluble Tanshinone II_A.