目的 优选薄荷油β-环糊精聚合物(β-CDP)微球包合的最佳工艺。方法 采用饱和水溶液法制备薄荷油β-CDP微球包合物,通过L9(34)正交试验设计以回归分析法为指标对制备工艺进行了优化;分别用红外光谱、综合热分析和X射线衍射分析法对薄荷油β-CDP微球包合物进行表征。结果 最佳制备工艺条件是选定A2B2C1D3;影响因素的大小依次为:β-CDP微球和与水之比＞β-CDP微球和薄荷挥发油投料比＞包合温度＞包合时间;IR、XRD、TGA等方法证明了包合物的生成。结论 薄荷油的包合方法合理可行。

Objective To optimize the including preparation for peppermint oil-β-cyclodextrin polymer (β-CDP) microsphere inclusion compound. Methods Peppermint oil-β-CDP microsphere inclusion compound was prepared by using co-precipitation. The preparation process was optimized through the L9(34) orthogonal test design and regression analysis. Peppermint oil-β-CDP microsphere inclusion compound was characterized by infrared (IR) spectroscopy, thermogravimetric analysis (TGA), and X-ray diffraction (XRD). Results The best technological condition was A2B2C1D3, and the order of the influence factors was the proportion of β-CDP microsphere and water > the percentage of peppermint oil in β-CDP microsphere > inclusion temperature > inclusion time. The formation of peppermint oil β-CDP microspheres inclusion compound was proved by the results of IR, XRD, TGA analyses. Conclusion The method is reasonable and feasible.

国家自然科学基金资助项目(50573046);陕西科技大学研究生创新基金资助