[关键词]
[摘要]
目的 研究冬青科冬青属植物枸骨Ilex cornuta根中的化学成分。方法 运用硅胶、Sephadex LH-20柱色谱对枸骨根中的化学成分进行分离,通过理化常数、质谱和核磁技术鉴定化合物。结果 从枸骨根中分离并鉴定了11个化合物,分别为β-谷甾醇(1)、羽扇豆醇(2)、白桦酸(3)、常春藤皂苷元(4)、3β-乙酰基-28-羟基-乌苏醇(5)、乌苏酸(6)、19α-羟基乌苏酸(7)、3β-乙酰基-乌苏酸(8)、23-羟基-乌苏甲酯(9)、庚酸(10)、β-胡萝卜苷(11)。结论 化合物4、5、8、9为首次从该属植物中分离得到。化合物3为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of the roots of Ilex cornuta.Methods The compounds were isolated and purified by silica gel,Sephadex LH-20,medium pressure column chromatography,and semi-preparative liquid chromatography,and their structures were elucidated by chemical properties and spectroscop analyses.Results Eight compounds were isolated and their structures were identified to be β-sitosterol(1),lupeol(2),betulonic acid(3),hede-ragenin(4),3β-acetoxy-28-hydroxyurs-12-ene(5),ursolic acid(6),19α-hydroxy ursolic acid(7),3β-acetoxy-ursolic acid(8),23-hydroxyl-methyl ursolate(9),heptanoic acid(10),β-daucosterol(11).Conclusion Compounds 4,5,8,and 9 are obtained from this genus for the first time,and compound 3 is obtained from this plant for the first time.
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[基金项目]
苏州大学青年基金项目(2008);苏州大学大学生创新试验计划项目资助(2009DC03092)
