目的 为了寻找钩吻Gelsemium elegans的活性成分,对其化学成分进行研究。方法 运用正反相柱色谱、葡聚糖凝胶等分离技术,根据化合物的波谱数据鉴定化合物的化学结构。结果 从乙醇提取物的氯仿萃取部位分得8个化合物,分别鉴定为gelsemoxonmine Ⅱ(1)、koumine(2)、gelsemine Ⅰ(3)、胡蔓藤碱Ⅳ(4)、19-(Z)-koumidine(5)、19-(Z)-akuammidine(6)、4-(R)-gelsemine-N-oxide(7)和4-(S)-gelsemine-N-oxide(8)。结论 化合物1～7是首次从采自西双版纳的钩吻地上部分分离得到的钩吻类吲哚生物碱,化合物8为新天然产物。

Objective To study the chemical constituents from Gelsemium elegans aiming at searching for bioactive natural products.Methods Column chromatography techniques were used for separation and purification of the compounds and extensive spectral analysis spectrum were employed for structural elucidation.Results Eight compounds were isolated from the aerial part of G.elegans and their structures were identified as gelsemoxonmine Ⅱ(1),koumine(2),gelsemine Ⅰ(3),humantenine Ⅳ(4),19-(Z)-koumidine(5),19-(Z)-akuammidine(6),4-(R)-gelsemine-N-oxide(7),and 4-(S)-gelsemine-N-oxide(8).Conclusion Compounds l-7 are isolated from the aerial part of this plant.Compound 8 is isolated for the first time as natural substance.

云南省自然科学基金(2003C0061M)