目的 建立一种客观有效的评价黄芩内在质量的新模式。方法 广泛收集代表性黄芩样品，制备各样品的供试液，分别测定其HPLC色谱指纹图谱及抑菌效果，并用数学方法将指纹图谱数据与抑菌率关联。结果 由建立的数学模型计算得到的20批黄芩验证样品的抑菌率值与实验测得值的偏差率全部在10%以内，其中15批样品的偏差率在5%以内。结论 运用所建立的数学模型基本能够实现通过指纹图谱数据对黄芩药材抑菌效果的评价。

Objective To establish a new mode for quality evaluation of Scutellariae Radix objectively and effectively. Methods To collect Scutellariae Radix extensively, prepare test liquid of every sample, examine its HPLC fingerprints and pesticide effectiveness, and then correlate the HPLC fingerprints with the inhibitory rates by mathematics. Results The other 20 batches of Scutellariae Radix were examined. The bias proportions of the inhibitory rates between the ones calculated by the established mathematical model and the ones from experimental measurement were less than 10% in all, there were 15 samples whose bias proportions are less than 5%. Conclusion The mathematic model can basically be used to evaluate the efficacy of Scutellariae Radix by HPLC fingerprints.

国家“十一五”支撑计划项目（2006BAI06A02－03）；山东省科学院博士基金项目（鲁科院字[2008]102号）