中药毒性是中药药性理论的核心之一。从历史角度，对中药毒性认识进行文献溯源，对中药毒性涵义与分级的传统与现代认识进行比较与分析，提出中药毒性的传统性与经验性、客观性、概念的整体性及一定的可控性观点，建议应结合中医药理论与实际，整合与运用多种现代科学技术方法，开创中药毒性研究的新思路，对全面认识中药毒性、加强中药毒性研究、促进临床毒性中药的安全使用具有积极意义。

The toxicity of Chinese materia medica (CMM) is one of cores of the property theory of CMM. From the perspective of history, the literature source of the understanding on CMM toxicity was traced; The traditional and contemporary understanding about the meaning and classification of CMM toxicity was compared and analyzed; The ideas on CMM toxicity with the feature of tradition, experience, objectivity, the integrity of the concept, and some of the controllability were proposed; The theory and practice of traditional Chinese medicines should be combined in order to effectively integrate and apply various modern scientific and technical methods, and create new ideas about toxicity studies of CMM, which has the important significance on the comprehensive understanding about CMM toxicity, strengthening the research on CMM toxicity, and promoting the safety of CMM in clinical use.