近年来海洋天然产物越来越引起科学家们的注意,在浩瀚的海洋中存在着大量令人激动、活性独特、结构新颖的次生代谢产物。海洋天然产物已成为发现重要先导药物和新的生物作用机制的主要源泉。对目前海洋天然产物研究概况进行综述,其中重点介绍大环内酯类和聚醚类等化合物。

Ocean is a unique and excellent source that provides a diverse array of intriguing natural products. Marine natural products have been demonstrated with significant and extremely potent biological activities, which captured the attention of natural products chemists in the past few decades? It is increas-ingly recognized that a wealth of fascinating natural products and novel chemical entities will play a dom- inant role in the discovery of useful leading compounds for the development of pharmaceutical agents and provide useful probes to lead to breakthroughs in a variety of life-science fields? The outline of marine nat-ural product research is summarized concisely and the emphasis is focused on the macrolides and polyethers in this paper.

河北省引进留学人员基金资助项目(2008-2010);河北省自然科学基金资助项目(08B032,C2010000489);河北省卫生厅基金资助项目(05089);河北省中医药管理局基金资助项目(2006053);河北医科大学教育科学研究重点课题(09zd-17)