目的研究紫芝Ganoderma sinense子实体的化学成分。方法通过反复硅胶、凝胶柱色谱进行分离纯化, 利用多种波谱技术鉴定化合物的结构。结果分离鉴定了4个化合物, 分别为紫芝酸(sinensoic acid, 1)、cere-broside D(2)、poke-weed cerebroside(3)、泥湖鞘鞍醇(hemisceramide, 4)。结论化合物为新化合物, 命名为紫芝酸(sinensoic acid), 其余化合物均为首次从灵芝属真菌中分离得到。

Objective To study the chemical constituents from the fungal fruiting bodies of Ganoderma sinense.Methods Individual constituents,isolated and repeatedly purified on silica gel and Sephadex LH-20 column chromatography,were identified by physicochemical constants and structurally elucidated by spectral methods.Results Four compounds were isolated and identified as: sinensoic acid(1),cerebroside D(2),poke-weed cerebroside(3),hemisceramide(4).Conclusion Compound 1 is a new compound,others are isolated from the fungus of Ganoderma for the first time.

科技部科技基础性工作专项 (2007Fy130100)