中药复方药效物质基础(material basis for efficacy of Chinese herbal formula)的是目前亟待解决的中药领域的关键问题之一, 而目前对中药复方药效物质基础的界定, 学术界尚有分歧。中药复方药效物质基础是某一特定复方经与人体作用后在发挥疗效的特异性的靶器官、靶组织中达到一定浓度并发挥生物学效应的直接或间接来源于该复方的非内源性活性物质的总和。中药复方药效物质基础的系统药理学评价是中药现代化和国际化的核心与基石, 而中药质量控制是中药复方药效物质基础的系统药理学评价的先决条件。

Systematic pharmacological evaluation of material basis for the efficacy of Chinese herbal formula is one of the key issues in Chinese materia medica(CMM),which is in urgent need of solution.However,its scientific connotation is still controversial in academic circles.The material basis for the efficacy of Chinese herbal formula is the total non-endogenous bioactive compound(derived either directly or indirectly from this formula) exerting the therapeutic effects,which is generated by the interaction of the formula with human body and reaches certain concentration in the target organs or tissues.Systematic evaluation of material basis for the efficacy of Chinese herbal formula is the cornerstone of modernization and internationalization of CMM,while the quality control of CMM is its prerequisite.

澳门特别行政区科学技术发展基金资助项目 (029/ 2007/ A2)