目的：制备包封率较高且具有较好缓释性能的盐酸青藤碱多囊脂质体。方法：用复乳法制备盐酸青藤碱多囊脂质体, 以包封率和囊形为考察指标, 采用均匀设计优选最佳处方和工艺, 并考察其形状、粒径及体外释放性能。结果：制得的盐酸青藤碱多囊脂质体包封率在80%以上, 形状圆整, 粒径较均匀, 多数分布在20~30μm, 体外释放符合Higuchi方程, 释药t1/2为52. 7 h。结论：盐酸青藤碱多囊脂质体处方工艺稳定可行, 包封率高且具有良好的缓释特性。

Objective: To prepare the sinomenine hydrochloride multivesicular liposomes with high antrapment efficiency and sustained release character. Methods: Multiple emulsion method was used to prepare the sinomenine hydrochloride muhivesicular liposomes. Uniform designwas applied to optimize the formulation and pharmaceutical process. The shape, the particle size, and the release charcter of the liposome were evaluated. Results: The sinomenine hydrochloride multivesicular liposomes prepared were spherical and the size ofmajority particleswas in therangeof 20-30um and well distributed. The encapsulation efficiency was more than 80%and its in-vitro release profile accorded well with the Higuchimodel with t1/2 up to 52. 7 h. Conclusion: The formulation and pharmaceutical processof the sinomenineby-drochloride multivesicular liposomesare stable and feasible with the high encapsulation efficiency and good sustained-release character.