目的 优选痹痛宁贴剂的处方基质配比,对其体外透皮吸收行为进行考察。方法 采用U₆(6⁶)均匀设计安排试验,利用改良Franz扩散池进行离体皮肤体外渗透实验。以东莨菪碱和乌头碱24h累积渗透量为指标优选处方配比。结果 基质比例分别为PVA11.02%、PVP29.93%、甘油7.42%、氮酮4.95%、丙二醇11.06%,贴剂具有最大的累积释药量,释药曲线符合Higuchi方程。结论 采用均匀设计法优选的配方组成符合骨架控释型透皮给药系统的要求。

Objective To optimize the prescription matrix proportion of Bitongning Patch and observe its percutaneous absorption in vitro.Methods U₆(6⁶)Uniform design was performed to investigate the influence of scopolamine and aconitine in the proportion for 24 h cumulative permeation in vitro.The drug permeation behavior through excised mouse skin was studied with improved Franz diffusion cell.Results With the matrix ratio for PVA：11.02％,PVP：29.93％,glycerol：7.42％,azone：4.95％,and propanediol：11.06％,respectively,the Patch had the maximal cumulative permeation amount and cumulative permeation curve coincided with the Higuchi Equation.Conclusion The prescription composition optimized by uniform design meets the requirement of skeleton-controlled transdermal delivery system.