目的 研究民族药观赏獐牙菜Swertia decora的化学成分,寻找活性物质。方法 用系统溶剂提取,常规硅胶柱色谱和薄层色谱进行分离纯化,根据化合物的物理、化学性质,UV、MS、NMR、HMPC、HMQC等波谱手段及HPLC对照等鉴定其结构。结果 从观赏獐牙菜的低极性部分分离得到3个化合物,分别鉴定为1-羟基-4,5,6,7-四甲氧基酮即观赏獐牙菜酮-(1-hydroxy-4,5,6,7-tetramethoxy-9H-xanthen-9-one,)、5,7,3′,4′-四羟基黄酮即木犀草素(luteolin,)和3,5,7,3′,4′-五羟基黄酮即槲皮素(quercetin,)。结论 化合物Ⅰ为-新化合物,命名为观赏獐牙菜圸酮-Ⅰ(swertiadecoraxanthone-),另2个化合物均为首次从该植物中分离得到。化合物的五氧取代类型也为首次在獐牙菜属植物中发现。

Objective To study the chemical constituents of Swertia decora,a traditional herb used to treat hepatitis by the minority.Methods The constituents were separated and purified by column chro-matography with silica gel.Their structures were identified on the basis of spectral analysis such as UV,MS,NMR,HMPC,HMQC and by HPLC.Results Three compounds were isolated hom the chloroform part and ethyl acetate part of the extracts.Their structures were identified as 1-hydroxy-4,5,6,7-4etra-methoxy-9H-xanthen-9one(swertiadecoraxanthone-I,I),5,7,3',4'-tetrahydroxyflavone(1uteofin,Ⅱ),and 3,5,7,37,4'-pentahydroxyflavone(quercetin,Ⅲ),respectively.Conclusion Swertiadecora-xanthone-I is a new compound and the other two are found from this plant for the first time.The pen-taoxygenated patterns of compound I is also found for the first time in the plants of Swertia L.

云南省教育厅资助项目(0141577)