目的探讨油菜资源中吲哚硫苷降解物对肿瘤的抑制作用及对免疫功能的影响。方法分别将两种不同提取法制备的高、低浓度的吲哚硫苷对S₁₈₀小鼠ig给药,ip环磷酰胺。结果吲哚硫苷降解物2号高浓度和吲哚硫苷降解物1号低浓度治疗组与生理盐水对照组相比有明显的抑制作用,能增加淋巴细胞转化率。结论吲哚硫苷降解物可能是通过增强机体免疫功能来抑制移植性肿瘤生长,起到抗肿瘤的作用。

Object To study the antitumor and immunological effect of IN DL-GLN in rape on the cancerous mice transplanted S₁₈₀ cell. Methods The treatment group was administrated(ig)IN DL-GLN at two doses(high and low dose),control group was administrated(ip)cyclophophamide.The mechanism of its antitumoraction was assessed by lymphocyte convertion test.Results Both high(No.2)and low (No.1)doses of INDL-GLN exhibited significant antitumor effects as compared with the control group,the lymphocyte convertion rate was increased,respectively.Conclusion IN DLO-GLN has great antitumor activity and immunostimulation,its antitumor mechanism may be due to its immunostimulation.

国家自然科学基金资助项目(39770452)