龙胆苦苷的保肝作用研究

刘占文; 陈长勋; 金若敏; 史国庆; 宋纯清; 胡之璧; LIU Zhan-wen; CHEN Chang-xun; JIN Ruo-min; SHI Guo-qing; SONG Chun-qing; HU Zhi-bi

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主办：天津药物研究院中国药学会

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首页 > 过刊浏览>2002年第卷第1期 >2002(1):47-50

龙胆苦苷的保肝作用研究

Studies on liver-protection and promoting bile secretion of gentiopicroside

发布日期：2015-01-07

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[摘要]

目的研究ig 龙胆苦苷的肝保护作用及与龙胆草药理作用的一致性。方法给动物ig 给药,用CCl_{4、D-GlaN 造急性肝损伤模型,测定小鼠血清ALT、AST 及肝组织中谷胱甘肽过氧化物酶含量,采用麻醉大鼠,测定胆汁分泌量及胆汁成分。结果 ig 龙胆苦苷后能明显降低CCl_{4 急性肝损伤小鼠血清ALT、AST 水平及增加肝组织中谷胱甘肽过氧化物酶活力,大鼠胆流量明显增加,胆汁中胆红素浓度提高。结论龙胆苦苷具有明显肝保护作用。}}

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[Abstract]

Object To study the liver-protection and bile promoting secretion of gentiopicroside administrated ig in rat. Methods Gentiopicroside was administrated ig to the mice with liver injury induced by CCl_{4 and D-GlaN. ALT, AST levels in serum and GSH-Px activity in liver were examined. The bile flow rate and the concentration of the main components in the bile of rats after ig administration of gentiopicroside were estimated. Results Gentiopicroside administrated ig decreased the serum ALT and AST levels, increased the liver GSH-Px activity in the mice treated with CCl_{4, promoted the secretion of bile and increased the concentration of bilirubin in the bile. Conclusion Gentiopicroside administrated ig exhibited significant liver-protection and promoting bile secretion.}}

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[基金项目]

国家“九五”攻关课题“龙胆苦苷质量标准的规范化研究”,批准号969030203

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