目的:为进一步验证"复方效应成分动力学"假说提供临床药物动力学(PK)研究依据.方法:用已建立的方法[1], 研究健康自愿者一次口服川芎汤(1g/kg)、川芎芍药(1:1)汤(2g/kg)后血清中阿魏酸(FA)的药动学.结果:两组的血药-时曲线均表现为双峰现象, 属开放性一室模型.川芎汤和川芎芍药汤组FA的主要药动学参数分别如下:Ka(L/min)=0.2816±0.1327和0.1206±0.0621;Cmax(ng/mL)=100.0844±34.6955和47.5676±28.2358;AUC(ng/min·mL)=15734.88±7063.77和5717.92±5590.99;Cl/F(s)(L/min)=0.0028±0.0014和0.0416±0.0254;V/F(c)(ng/mL)=0.6108±0.2800和2.0415±1.1063.结论:川芎配伍芍药明显影响川芎在血清中FA的吸收、分布和排泄等.

To provide further clinical pharmacokinetic evidenc e in support of the hypothesis “Phamacokinetic Effect of Compound Herbal Prescr iptions.” Healthy volunteers were given either a single oral dose (1 g/kg) of LW decoction or a single oral dose (2 g/kg) of LW and PV (1∶1) decoction, follo wed by the determination of serum ferulic acid (FA), one of the active principle in LW, as described in our previously published report［１］. Both group s gave serum FA concentrationtime curves with two peaks showing their open one compartment model nature. The main pharmacokinetic parameters of LW and LW+PV decoctions were: Ka(L/min)=0.281 6±0.132 7 and 0. 120 6±0.06 2 1； Cmax(ng/mL)=100.084 4±34.695 5 and 47.567 6±28 .235 8; AUC(ng/min·mL)=15 734.88±7 063.77 and 5 717.92±5 5 90.99; Cl/F(s)(L/min)=0.002 8±0.001 4 and 0.041 6±0.025 4 ; V/F(c)(ng/mL )=0.610 8±0.280 0 and 2.041 5±1.106 3. The above results indicated that PV coul d influence the absorption, distribution and elimination of FA when LW was presc r ibed in combination with PV. This provided an evidence in support of the hypoth esis of “Pharmacokinetic Effect of Compound Herbal Prescriptions”.

国家自然科学基金资助项目 (No.39870932,30070912);高等学校骨干教师计划(教育部)