鬼针草中的新天然成分──鬼针聚炔甙(bipinnatpolyacetylenicloside)能明显抑制巴豆油诱发的小鼠耳壳肿胀及蛋清性足肿胀,降低大鼠棉球肉芽肿重量,还能显著抑制小鼠毛细血管通透性和醋酸至炎的大鼠的白细胞游走,其抗炎效果大多与地塞米松组无显著差异甚至有的作用略强,鬼针草中的黄酮混晶也有较好的抗炎作用。

Bipinnatpolyacetylenic loside-anew natural constituent isolated from Bidens bipinnata,produced sig-nificant inhibitory effects on swelling of mice ear induced by croton oil and hind paw edema induced by egg white,decreased the weight of cotton pellet granuloma implanted in rats,and also greatly inhibited blood cap-illary permeability of mice and leukocyte movement induced by acetic acid in rats. Compared with that of dex-amethasone,no significant difference and even slightly more potent effects were observed. The flavones in B.bipinnata also exhibited better anti-inflammatory effects.

山东省自然科学基金