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[摘要]
用血小板聚集实验(exvivo)、大鼠颈动脉血栓形成和急性脑水肿动物模型对芪棱片的药理作用进行观察。结果表明:芪棱片可明显抑制ADP诱导的大鼠血小板聚集(P<0.001), 对电刺激大鼠颈动脉血栓形成有显著的延缓作用(P<0.01), 本品不影响脑水肿时的Na+含量升高, 而对水肿引起的K+含量降低有改善(P<0.01), 对脑水肿有明显缓解作用。本实验结果为芪棱片在临床上用于预防缺血性中风提供了实验依据。
[Key word]
[Abstract]
Effects of Qileng table on platelet aggregation, thrombosis and acute cerebral edema were investigated. Qileng table significantly inhibited platelet aggregation(ex vivo) induced by ADP(P<0.001), relarded thrombosis caused by electric current stimulation(ex vivo) induced by ADP(P<0.001), retarded thrombosis caused by electric current stimulation of rat carotid arteries(P<0.01). It also prevented K+ loss in acute cerebral edema(P<0.01) and decreased brain water content during edema. There results suggested that Qileng table may used for the prevention of ischemic stroke.
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