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[摘要]
灵芝浸膏给小鼠灌胃,每日1.0g/2.0g/kg,连续3d,末次给药后1h,用束缚水浸法造成应激性溃疡。结果表明,灵芝能显著降低溃疡的发生率及减少胃粘膜出血。灵芝拮抗乙酰胆碱对离体肠肌的收缩,IC50为8.5×11-4g/ml。灵芝抑制应激性溃疡的形成,可认为是其对外周副交感神经的阻断作用。
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[Abstract]
Mice were pr.treat0d P0 with 0.4g/kg, 1.0g/kg, 2.0g/kg Lingzhi aqeous extract once dailY for 3daYs respectiv.lY. lh after the last d0se, they were kept under restraint plus water-imm-ersiou stress for 22h.Lingzhi 1.0g/kg, 2.0g/kg, an d at roping 0.04g/kg markedly dec reased ulcer formation and hemorrhage incidences comparcd with control (P0 .01 ). Lingzhi in differ-cnt doages could produced by acetylcholine. Its IC,, was found to be 8.5 x 10-'g/ml. Ulccr fo-rmation uudcr strcss condition is due to stimulation of the excessive central hypothalamus andParasymPathctic nervous system5 especially vaga1 ove racti vity p1ays au important role. T he results suggest that Lingzhi posscsses a blocking effects on peripheral pa rasympathetic nervous syste m
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