宋艳春,刘湘梅,李秀娟,宋士岳.刺五加注射液对大鼠长期毒性试验的研究[J].药物评价研究,2010,33(1):1-4
刺五加注射液对大鼠长期毒性试验的研究
Research of long-term toxicity of Ciwujia Injection in rats
投稿时间:2010-01-05  
DOI:10.7501/j.issn.0253-6376.[year].[issue].[sequence]
中文关键词:  刺五加注射液;长期毒性;大鼠
英文关键词:Ciwujia Injection (Acanthopanax Injection); long-term toxicity; rat
基金项目:
作者单位
宋艳春1,刘湘梅2,李秀娟2,宋士岳2 1 牡丹江农管局中心医院,黑龙江 密山 158300; 2 黑龙江乌苏里江制药有限公司,黑龙江 虎林 158400 
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中文摘要:
      目的:观察大鼠连续静脉/腹腔交替注射刺五加注射液产生的毒性反应与靶器官损害的可逆性。方法:通过血液学、血液生物化学和病理组织学检查,观察注射刺五加注射液对大鼠的毒性反应及程度。结果:连续静脉/腹腔交替注射刺五加注射液4 周,动物全部存活,高、低剂量组动物未见明显毒性反应,停药后各剂量组均未见迟缓性毒性发生。结论:刺五加注射液连续静脉/腹腔交替注射对大鼠体重增长率、各主要器官脏器系数、血细胞和血液生化指标均无显著影响,病理组织学检查亦未见毒性病理改变,停药后2周亦未见延迟毒性,即刺五加注射液对大鼠无明显毒性。
英文摘要:
      Objective: To observe the toxic reactions and reversibility of target organ damage by alternatively continuous iv and ip injection of Ciwujia Injection (Acanthopanax Injection) in rats. Methods: The degree of toxicity was observed in rats by injection of Ciwujia Injection with hematological, blood biochemical and histopathological methods. Results: All animals survived after continuous iv and ip injection of Ciwujia Injection for 4 weeks. High-dose and low-dose group animals had no significant toxicity and no delayed toxicity occurred after treatment with various doses. Conclusion: Body weight growth rate, organ coefficient of major organs, blood cells and blood biochemical parameters had no significant effect after alternatively continuous iv and ip injection of Ciwujia Injection in rats, histopathological examination are also no toxic pathological changes, no sign of delayed toxicity was examined after three weeks of drug withdrawal, that is, Ciwujia Injection had no significant toxicity.
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