于 飞,高 晶,曾 勇,刘昌孝.大鼠静脉注射康莱特注射液的药动学研究[J].药物评价研究,2009,32(2):92-95
大鼠静脉注射康莱特注射液的药动学研究
Pharmacokinetics of Kanglaite Injection by intravenousadministration in rats
投稿时间:2009-04-20  
DOI:10.7501/j.issn.0253-6376.[year].[issue].[sequence]
中文关键词:  康莱特注射液;静脉注射;甘油三酯;药动学
英文关键词:Kanglaite Injection; intravenous injection; triglyceride (TG) , pharmacokinetics
基金项目:国家重点基础研究计划项目(973计划)(2004BC581902)
作者单位
于 飞1,2,高 晶1,曾 勇1,刘昌孝1  1 天津药动学与药效动力学省部共建国家重点实验室,天津 300193 2 天津大学化工学院 制药工程专业,天津 300072 
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中文摘要:
      目的:研究康莱特注射液在正常大鼠体内的药动学。方法:采用甘油三酯试剂盒检测康莱特注射液经尾iv后大鼠血清中外源性甘油三酯的浓度变化,外源性甘油三酯浓度为测定血样中甘油三酯扣除本底后的浓度,采用3P97药代软件计算药动学参数。Cmax为实测值,AUC计算采用梯形法。结果:康莱特注射液10、5 mL/kg剂量的主要药动学参数:Cmax分别为(8.532±1.031)、(5.418±0.764)mmol/L,AUC0-t分别为(13.248±3.692)、(5.339±1.219)mmol/L?h,Vc分别为(1.030±0.131)、(0.756±0.150)L2/(kg·mol),CLs分别为(0.838±0.319)、(0.975±0.330)L2/(kg·mol·h),t 1/2α 分别为(0.481±0.168)、(0.322±0.109)h,t 1/2β分别为(1.452±0.776)、(1.384±0.404)h。结论:康莱特注射液经尾iv给药后在大鼠体内的药动学过程经拟合为二室模型。
英文摘要:
      Objective: To study the in vivo pharmacokinetics of Kanglaite Injection in rats. Methods: The concentration change of exogenous triglyceride (TG) in rat serum was detected by TG Kit after iv administration of Kanglaite Injection in tail. The concentration of exogenous TG was the concentration after the background subtraction. Pharmacokinetic parameters were calculated by 3P97 software. Cmax was the true value, AUC is obtained by the trapezoidal rule. Results: At the dosages of 10 and 5 mL/kg the main pharmacokinetic parameters of Kanglaite Injection were as follows: Cmax=(8.532 ± 1.031) and (5.418 ± 0.764) mmol/L, AUC0-t=(13.248 ± 3.692) and (5.339 ± 1.219) mmol/L?h, Vc=(1.030 ± 0.131) and (0.756± 0.150) L2/(kg·mol), CLs=(0.838 ± 0.319) and (0.975 ± 0.330) L2/(kg·mol·h), t 1/2 α=(0.481 ± 0.168) and (0.322 ± 0.109) h, t 1/2 β=(1.452 ± 0.776) and (1.384 ± 0.404)h. Conclusion:The in vivo pharmacokinetic model of Kanglaite Injection after iv injection in rat tail is two compartment model.
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