[关键词]
[摘要]
氧化苦参碱具有抗高脂饮食性、CCl4性、CCl4/酒精性、二甲基亚硝胺性、半乳糖胺性、免疫性慢性肝损伤作用。氧化苦参碱是通过抗氧化、抗炎作用,减轻肝脏的氧化应激和炎症反应以及抑制成纤维细胞和肝星状细胞的活化以及细胞外基质生成,产生抗肝纤维化作用。氧化苦参碱还可通过促进胰岛素信号转导,改善胰岛素抵抗,抑制肝细胞吸收长链脂肪酸和脂肪酸合成并加速游离脂肪酸的β-氧化,产生抗脂肪肝作用。
[Key word]
[Abstract]
Oxymatrine has the effects to antagonize chronic liver injuries induced by high-fat diet, CCl4, CCl4/alcohol, dimethylnitrosamine, galactosamine, and immunity. Oxymatrine alleviates oxidative stress and inflammation of liver by antioxydation and anti-inflammation, decreases hepatic fibrosis by inhibiting activation of HSC and fibroblast, and inhibites synthesis of extracellular matrix. Oxymatrine has the effect against fatty liver by promoting insulin signal transduction to alleviate insulin resistance, inhibiting hepatocyte to absorb the long chain fatty acid, decreasing synthesis of fatty acid, and accelerating β-oxidation of free fatty acid.
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