[关键词]
[摘要]
苦参碱类生物碱对粒细胞性、单核细胞性、淋巴细胞性白血病、淋巴瘤和骨髓瘤等造血系统肿瘤细胞都有抑制增殖并诱导分化和凋亡作用。苦参碱和氧化苦参碱曾在临床上被试用于治疗白血病、多发性骨髓瘤或恶性淋巴瘤,结果发现苦参碱或氧化苦参碱与化疗药联用,能提高化疗药的疗效,降低化疗药的毒性作用。
[Key word]
[Abstract]
Matrine-type alkaloids inhibit proliferation,and induce differentiation and apoptosis in granulocytic,monocytic and lymphocytic leukemia cells,lymphoma cells,and myeloma cells.Matrine and oxymatrine have been tried to treat leukemia,multiple myeloma or malignant lymphoma in clinic.They were observed to induce the effects of increasing efficacy and attenuating toxicity in combination with chemotherapeutic.
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