目的 探讨丁苯酞注射液对急性大脑中动脉供血区卒中患者的疗效及对脑血管CO₂反应性（CO₂R）的影响。方法 选择2014年1月-2017年8月在河南大学附属南阳南石医院神经内科诊治的119例急性大脑中动脉供血区卒中患者，根据治疗方法的不同分为观察组69例与对照组50例。对照组采用常规药物治疗，观察组在对照组基础上联合丁苯酞注射液治疗，两组治疗观察28 d。比较两组临床疗效、简明智力状态检查量表（MMSE）评分、脑梗死体积及脑血管CO₂R变化情况。结果 观察组的总有效率为99.55%，显著高于对照组的88.00%（P<0.05）。治疗后两组的脑梗死体积都较治疗前显著下降（P<0.05），且观察组显著低于对照组（P<0.05）。两组治疗后的MMSE评分都显著高于治疗前（P<0.05），且观察组显著高于对照组（P<0.05）。治疗后两组的屏气指数都显著高于治疗前（P<0.05），且观察组显著高于对照组（P<0.05）。结论 丁苯酞注射液在急性大脑中动脉供血区卒中患者中的应用能改善脑血管CO₂R状况，提高治疗效果与缩小脑梗死体积，促进认知功能的恢复。

Objective To explore the effect of butylphthalide Injection on cerebral vascular CO₂ reaction (CO₂R) in patients with acute middle cerebral artery blood supply area stroke.Methods From January 2014 to August 2017,119 patients with acute middle cerebral artery blood supply area stroke were selected and were divided into the 69 patients in the observation group and the 50 patients of the control group accorded to the different treatment methods,the control group were treated with conventional drugs,the observation group were treated with Butylphthalide Injection on the basis of the control group,and the two groups were treated with 28 d.The changes of CO₂R in cerebral vessels were recorded.Results All the patients were completed the treatment.The total effective rates of the observation group and the control group were 92.8% and 60%,respectively,and the observation group were significantly higher than the control group (P<0.05).After treatment,the volume of cerebral infarction in the two groups were decreased significantly (P<0.05),and the decreased values in the observation group were significantly more than that in the control group (P<0.05).After treatment,the MMSE scores of the two groups were significantly higher than those before treatment,and the score of the observation group were also higher than that of the control group after treatment (P<0.05).After treatment,the breath holding index of the observation group and the control group were significantly higher than those before treatment (P<0.05),and the observation group were also higher than that of the control group (P<0.05).Conclusion The application of Butylphthalide Injection in stroke patients with acute middle cerebral artery blood supply area stroke can improve the status of cerebral vascular CO₂R,improve the therapeutic effect and reduce the volume of cerebral infarction,and promote the recovery of cognitive function.