[关键词]
[摘要]
双膦酸盐类药物用于预防与治疗骨吸收相关疾病,包括第1代的依替膦酸二钠、替鲁膦酸二钠、氯膦酸二钠,第2代的帕米膦酸二钠、阿仑膦酸钠,第3代的利塞膦酸钠、伊班膦酸钠、唑来膦酸等。该类药物口服达峰时间较短,吸收率偏低,生物利用度很低;骨结合部分的半衰期较长,药物留存时间也较长。与双膦酸盐联用产生相互作用的药物主要为:含有二价阳离子药物、其他双膦酸盐药物、华法林、苯妥英、非甾体类抗炎药、抗癌药、激素、H2受体拮抗剂以及肾毒性药物。从药动学角度解释双膦酸的药物相互作用,以避免不良反应发生。
[Key word]
[Abstract]
Bisphosphonates including the first generation of etidronate disodium,tiludronate disodium and clodronate disodium,the second generation of pamidronate and alendronate,the third generation of risedronate sodium,ibandronate and zoledronic acid,and etc,are used to prevent and treat bone resorption diseases.The oral bisphosphonates have short tmax,low absorption rate and low bioavailability.The half-life and drug retention time of the bone-binding part is long.The drugs that interact with bisphosphonates are mainly:divalent cation-containing drugs,other bisphosphonate drugs,warfarin,phenytoin,non-steroidal anti-inflammatory drugs,anticancer drugs,hormones,H2 receptor antagonists and nephrotoxic drugs.The drug interactions of bisphosphonates can be explained from the perspective of pharmacokinetics to avoid adverse drug reactions.
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[基金项目]