[关键词]
[摘要]
过氧化物酶体增殖物受体(PPARs)是细胞能量代谢的主要调节因子,PPARs的3种亚型在多种肿瘤细胞中具有不同的转录活性与效应,能量代谢稳态对细胞的命运至关重要,关于肿瘤的能量代谢一直是热点问题。所有细胞活动都强烈依赖于分解代谢和合成代谢途径之间的平衡,破坏能量平衡和微环境,将表现出一系列的代谢改变包括葡萄糖消耗增加,线粒体呼吸的减少,细胞死亡抗性增强,所有这些都是癌症进展的原因。了解癌症中的代谢过程和阐明PPARs的调控机制会产生新的治疗策略。
[Key word]
[Abstract]
Peroxisome proliferator-activated receptors (PPARs) are the major regulators of cellular energy metabolism.The three subtypes of PPARs have different transcriptional activities and effects in various tumor cells.And the energy metabolism of tumors has always been a hot spot problem.Energy metabolism homeostasis is critical to cell fate because all cellular activities are strongly dependent on the balance between catabolic and anabolic pathways.Destruction of energy balance and microenvironment will show a cascade of metabolic changes including increased glucose consumption,decreased mitochondrial respiration,and increased cell death resistance,all of which are responsible for cancer progression.Understanding the metabolic processes and elucidating the regulation mechanisms of PPARs will lead to new therapeutic strategies.
[中图分类号]
[基金项目]
国家自然科学基金项目(81573496,81773989)