目的 探究舍曲林联合丁苯酞在改善急性脑梗死患者认知功能及对其血清指标的影响。方法 选取2015年1月-2017年1月于佛山市第二人民医院进行治疗的75例急性脑梗死患者为研究对象，按照随机数字表法将其分为联合组（36例）与对照组（39例），其中对照组在常规治疗的基础上使用丁苯酞软胶囊进行治疗，联合组在对照组基础上加用舍曲林，两组患者治疗时间均为4周。治疗结束后对两组的治疗有效率进行评估对比，并对两组的血管内皮生长因子（VEGF）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平进行检测，使用美国国立卫生院研究院神经功能缺损量表（NIHSS）对两组患者治疗前后的神经缺损情况进行评定，使用蒙特利尔认知评估量表（MoCA）对两组患者治疗前后的认知功能进行评定。结果 联合组治疗有效率为91.67%，高于对照组的64.10%，对比差异具有统计学意义（P<0.05）。两组治疗前VEGF、IL-6、TNF-α水平对比差异不具有统计学意义；治疗后，两组VEGF水平均升高，IL-6、TNF-α水平均降低，组内差异有统计学意义（P<0.05）；治疗后联合组VEGF水平高于对照组，IL-6、TNF-α水平低于对照组，差异具有统计学意义（P<0.05）。治疗前两组NIHSS、MoCA评分差异不具有统计学意义；治疗后两组NIHSS评分均降低，MoCA评分均升高，组内差异有统计学意义（P<0.05）；治疗后联合组NIHSS评分低于对照组，MoCA评分高于对照组，差异具有统计学意义（P<0.05）。结论 舍曲林联合丁苯酞用于急性脑梗死的治疗，能够提高患者治疗后的认知功能，可能与影响急性脑梗死患者的血清因子水平有关。

Objective To investigate the effect of butylphenol combined with sertraline on improving cognitive function and serum indexes in patients with acute cerebral infarction. Methods Seventy-five patients with cerebral infarction who were treated in our hospital from January 2015 to January 2017 were selected as experimental subjects and divided into combination group (36 cases) and control group (39 cases) according to the random number table method. The control group was treated with butylphenol on the basis of routine treatment. The combination group was given sertraline on the basis of the control group. The treatment time of both groups was 4 weeks. After the intervention, the treatment efficiency was evaluated The levels of vascular endothelial growth factor (VEGF), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the two groups were measured by using the National Institutes of Health, The NIHSS was used to assess the neurological deficits in both groups before and after treatment. Finally, the Cognitive Function before and after treatment in both groups was assessed by using the Montreal Cognitive Assessment Scale (MoCA).Results The effective rate of combination group was 91.67, which was higher than that of control group (64.10%), the difference was statistically significant (P<0.05). There was no significant difference in the levels of VEGF, IL-6 and TNF-(P<0.05). There was no statistical difference in the NIHSS and MoCA scores between the two groups before treatment (P<0.05), the level of VEGF in the combination group was significantly higher than that in the control group, the levels of IL-6 and TNF-α were lower than those in the control group (P<0.05). The scores of NIHSS in the combination group were lower than those in the control group after treatment, and the MoCA score was higher than that in the control group (P<0.05). Conclusion s Butylphthalide combined with sertraline in patients with cerebral infarction can significantly improve their cognitive function, while improving their serum factor levels.