目的 探讨甘味颗粒抗抑郁症的分子机制。方法 借助中药整合药理学平台（TCMIP），检索甘味颗粒所含的化学成分信息，建立甘味颗粒作用的潜在靶标和疾病靶标之间的相互作用网络；富集计算核心靶标，进行基因功能分析和通路分析，再进一步构建"中药材-化学成分-核心靶标-关键通路"多维关系网络。结果 对甘味颗粒预测共得到65个活性成分，涉及33个关键靶标，甘味颗粒通过作用于Rap1信号通路、神经系统、雌激素信号通路、促性腺激素释放激素信号通路、神经胶质瘤、甲状腺激素信号通路、血小板激活、谷氨酸能突触、心肌细胞肾上腺素能信号传导、循环系统等相关生物过程和代谢通路发挥治疗抑郁症的作用。结论 初步揭示了甘味颗粒抗抑郁的潜在活性成分及其可能的作用机制。

Objective To explore the molecular mechanism of Ganwei Granules on depressive disorder. Methods Based on the platform of Integrative Pharmacology of Traditional Chinese Medicine (www.tcmip.cn), the chemical composition information in Ganwei Granules were retrieved, an interaction network between potential targets and disease targets of Ganwei Granules was established. Then enrichment calculation of core targets for gene function analysis and pathway analysis was carried out to further construct the multi-dimensional relationship network of "Chinese medicinal materials-chemical composition-core target-key pathway". Results A total of 65 predicted active ingredients of Ganwei Granules interacted with 33 key targets related to depression. The of antidepression mechanism of Ganwei Granules might be associated with Rap1 signaling pathway, nervous system, estrogen signaling pathway, gonadotropin releasing hormone signaling pathway, glioma, thyroid hormone signaling pathway, platelet activation, glutamatergic synapse, adrenergic signal transduction in cardiac myocytes, circulatory system and other pathways. Conclusion This research may reveal the potential active ingredients of Ganwei Granules in treatment of depression and its possible mechanism.