[关键词]
[摘要]
为了解纳米原料作用于皮肤时的暴露情况和总体风险,探讨透皮吸收研究在纳米原料安全评估中的应用,对三联苯基三嗪、氧化锌、炭黑、二氧化钛、亚甲基双-苯并三唑基四甲基丁基酚5种已收录于欧盟化妆品法规的纳米原料的透皮吸收试验研究以及相关安全评估工作进行总结。结果显示皮肤对于这5种纳米原料具有较好的屏障作用,未来在进行纳米原料透皮吸收研究以及纳米化妆品、经皮给药纳米药物的安全性评价时,应充分考虑皮肤屏障作用的影响,结合纳米原料的质量规格关键参数进行逐案分析。
[Key word]
[Abstract]
In order to understand the percutaneous exposure and overall risk of nanomaterials when applied on skin, and to discuss the application of percutaneous absorption data in safety evaluation of nanomaterials, in this article, the authors summarized related research studies and safety evaluation work of five nanomaterials, such as triphenyltriazine, zinc oxide, carbon black, titanium dioxide, methylene bis benzotriazolyl tetramethyl butylphenol, that had been included in the EU regulation. The results show that skin is an effective barrier for these nanomaterials. In the future, for percutaneous absorption study of nanomaterials, as well as for the safety evaluation of nano-cosmetics and skin-applied nano-drugs, the influence of skin barrier function should not be ignored, and a case-by-case analysis with consideration of key parameters of the nanomaterial is necessary.
[中图分类号]
R944;R986
[基金项目]