目的 基于遥测技术建立适用于监测清醒自由活动状态下巴马小型猪心电、血压、体温等生理指标的动物模型，为其在安全药理学研究中的应用提供支持。方法 8只巴马小型猪（雌雄各半）经手术植入植入子，手术后恢复3~4周，经体格检查确认已完全恢复后，采用EMKA遥测系统连续监测至少24 h心电图、血压等生理指标，包括心率、PR间期、QRS间期、QT间期、校正QT （QTcv）间期、体温、收缩压（SBP）、舒张压（DBP）、平均动脉压（MBP），并于次周重复监测1次。对巴马小型猪的24 h指标变化进行分析，并与Beagle犬和食蟹猴数据进行种属间比对分析。结果 巴马小型猪的心电数据和血压数据昼夜节律均不明显；体温呈现明显的昼夜节律，白天体温高，夜间体温低；动物的心率、血压和体温均受外界影响比较大，与动物的活动呈现明显的相关性；与Beagle犬和食蟹猴比较，巴马小型猪的心率和人类最为相似，SBP仅稍高于人类。结论 通过体内植入植入子，成功建立了巴马小型猪植入式遥测动物模型；与Beagle犬和食蟹猴比较，巴马小型猪更适合用于药物对心血管系统影响的评价。

Objective To establish an animal model for monitoring electrocardiogram(ECG), blood pressure(BP) and body temperature(T) of Bama miniature pig in conscious and free movement state based on telemetry technology, and to provide support for its application in safety pharmacology research.Methods Eight Bama mini-pigs(male and female half) were implanted surgically and recovered for at 3-4 weeks.ECG, blood pressure and other physiological indexes[(including heart rate, PR interval, QRS interval, QT interval, corrected QT(QTcv) interval, body temperature, systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial pressure(MBP)] were monitored continuously by EMKA telemetry system for at least 24 hours.The monitoring was repeated in the next week.The 24 h indexes of Bama miniature pig were analyzed, and the data of Beagle dog and cynomolgus monkey were analyzed interspecies.Results The circadian rhythm of ECG and BP was not obvious in Bama miniature pig.The body temperature showed obvious circadian rhythm, which was high in daytime and low at night.The heart rate, blood pressure and body temperature of the animals were greatly influenced by the outside world, and showed obvious correlation with the activity of animals.Compared with Beagle dogs and cynomolgus monkeys, the heart rate of Bama minipigs was the most similar to that of humans, with only slightly higher systolic blood pressure, compared with that of humans.Conclusion Bama miniature pig model was successfully established by implanting seeds in Bama miniature pig, and it was proved that Bama miniature pig was more suitable for the evaluation of drug cardiovascular system than Beagle dog and cynomolgus monkey.

R965.1