[关键词]
[摘要]
目的 探讨小儿肠胃康颗粒联合消旋卡多曲颗粒治疗小儿病毒性腹泻的临床研究。方法 选取2019年1月-2019年12月阿坝藏族羌族自治州人民医院治疗的128例病毒性腹泻的患儿作为研究对象,采用随机数字法将患者分为对照组和观察组,每组各64例。对照组口服消旋卡多曲颗粒,1.5 mg/(kg·次),3次/d。观察组在对照组治疗的基础上开水冲服小儿肠胃康颗粒,5 g/次,3次/d。两组患儿治疗疗程均为1周。观察两组患者的临床疗效和临床症状改善情况,同时比较两组治疗前后的血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和生长分化因子-15(GDF-15)水平及肠道菌群变化情况。结果 治疗后,观察组总有效率为93.8%,明显高于对照组的81.2%,两组总有效率比较差异具有统计学意义(P<0.05)。治疗后,观察组腹泻改善时间、呕吐改善时间、发热改善时间及病毒转阴时间均明显低于对照组(P<0.05)。治疗后,两组IL-6、TNF-α及GDF-15水平均明显降低(P<0.05);治疗后观察组IL-6、TNF-α及GDF-15水平明显低于对照组(P<0.05)。治疗后,两组双歧杆菌、乳酸杆菌较治疗前均明显升高,而大肠杆菌较治疗前明显降低(P<0.05);治疗后,观察组双歧杆菌、乳酸杆菌明显高于对照组,而大肠杆菌明显低于对照组(P<0.05)。结论 小儿肠胃康颗粒联合消旋卡多曲治疗小儿病毒性腹泻的疗效显著,可以快速改善患儿的临床症状,缩短病毒转阴时间,同时降低肠道炎症反应,改善肠道菌群微生态平衡,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical study of Xiaoer Changweikang Granules combined with Racecadotril Granules in treatment of viral diarrhea in children. Methods A total of 128 children with viral diarrhea treated in the People's Hospital of Aba Tibetan and Qiang Autonomous Prefecture from January 2019 to December 2019 were selected as the research objects, and the patients were divided into control group and observation group by random number method, with 64 patients in each group. Patients in the control group were po administered with Racecadotril Granules, 1.5 mg/kg, three times daily. Patients in the observation group were po administered with Xiaoer Changweikang Granules on the basis of control group, 5 g/time, and three times daily. The course of treatment was 1 week in two groups. After treatment, the clinical efficacy and improvement of clinical symptoms in two groups were observed, the serum levels of IL-6, TNF-α, and GDF-15, and intestinal flora in two groups before and after treatment were compared. Results After treatment, the total effective rate in the observation group was 93.8%, which was significantly higher than 81.2% in the control group, and the difference between the two groups was statistically significant (P<0.05). After treatment, the improvement time of diarrhea, vomiting, fever and virus turning negative in the observation group were significantly shorter than those in the control group (P<0.05). After treatment, the levels of IL-6, TNF-α, and GDF-15 in two groups were significantly decreased (P<0.05). And the levels of IL-6, TNF-α, and GDF-15 in the observation group were significantly lower than those in the control group (P<0.05). After treatment, bifidobacteria and lactobacillus in two groups were significantly increased, while escherichia coli was significantly decreased (P<0.05). After treatment, bifidobacteria and lactobacillus in the observation group were significantly higher than those in the control group, while escherichia coli was significantly lower than that in the control group (P<0.05). Conclusion Xiaoer Changweikang Granules combined with Racecadotril Granules in treatment of viral diarrhea in children has significant curative effect, which can quickly improve the clinical symptoms, shorten the time of virus turning negative, reduce intestinal inflammation, and improve the intestinal microecological balance, which has certain clinical popularization and application value.
[中图分类号]
R975
[基金项目]
四川省卫生和计划生育委员会科研课题(2017PJ0082)