[关键词]
[摘要]
目的 评价注射用益气复脉(冻干)联合尼可地尔治疗气阴两虚型微血管性心绞痛的临床疗效和安全性。方法 选择2017年4月-2019年6月河北省退役军人总医院收治的气阴两虚型微血管性心绞痛患者80例,随机分为对照组和观察组(各40例)。对照组给予基础治疗+口服尼可地尔5 mg/次,3次/d;观察组在对照组治疗基础上+注射用益气复脉(冻干)5.2 g溶于9%生理盐水250 mL中,静脉滴注1次/d。两组均连续治疗14 d。比较两组的临床疗效、Duke运动平板评分和中医气阴两虚证候疗效。结果 治疗前两组患者的Duke运动平板评分和气阴两虚证候评分没有统计学差异。治疗后,观察组的治疗总有效率为87.50%,对照组为65.00%,两组比较差异具有统计学意义(P<0.05);两组得Duke运动平板评分均较治疗前提高(P<0.05),且观察组的Duke运动平板评分及危险分层均优于对照组,两组比较差异有统计学意义(P<0.05);两组气阴两虚证候评分均有改善(P<0.05),且观察组的中医证候有效率明显优于对照组(P<0.05)。两组未出现与治疗相关的不良反应。结论 对于气阴两虚型微血管性心绞痛的患者,在常规西药基础上加注射用益气复脉(冻干)治疗较单独使用西药的效果明显,且比较安全。
[Key word]
[Abstract]
Objective To observe the clinical effect of Yiqi Fumai Lyophilized Injection combined with nicorandil in the treatment of microvascular angina with Qi and Yin deficiency. Methods A total of 80 patients with microvascular angina with Qi and Yin deficiency were randomly selected and divided into the control group (n=40) and the observation group (n=40). The patients in control group were treated with western medicine starardied treatment + po nicorandil 5 mg, 3 times per day, and the patients in observation group were treated as control group + Yiqi Fumai Lyophilized Injection 5.2 g + 0.9% sodium chloride injection 250 mL, intravenous drip, once per day, and two groups were treated 14 days. Clinical efficacy, Duke exercise palte score, Traditional Chinese Medicine (TCM) symptom scores and efficacy were compared between the two groups before and after treatment in two groups were compared. Results After treatment, the total effective rate of treatment of the observation group was 87.50%, the total effective rate of control group was 65.00%, and the effect of the observation group was obviously better than that of the control group, and the difference was statistically. Duke exercise plate score showed that the score and risk stratification in the observation group were better than those in the control group (P<0.05). And the total effective rate of TCM symptom scores and efficacy were compared between the two groups before and after treatment, and there was statistical difference between the two groups (P<0.05). Conclusion It is more effective to add Yiqi Fumai Lyophilized Injection on the basis of conventional western medicine than western medicine alone for patients with microvascular angina pectoris.
[中图分类号]
R285.6;R286.2
[基金项目]