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[摘要]
目的 系统评价康复新液治疗复发性阿弗他溃疡(RAU)的疗效。方法 计算机检索2019年4月前中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普中文期刊全文数据库(VIP)、万方数据库、Co-chrane图书馆临床对照试验资料库(CCRCT)、江苏省工程技术文献信息中心、Pubmed、Sciencedirect中的相关文献,并对最终符合纳入标准的研究数据采用Revman 5.3进行Meta-分析。结果 共纳入13项研究(包含1 353例患者)。Meta-分析结果显示,康复新液(治疗组)治疗复发性阿弗他溃疡的总有效率[OR=5.45,95%CI(3.77,7.88),P<0.000 01]显著高于西瓜霜喷剂和(或)氯己定含漱液(对照组)。治疗组的平均溃疡期[SMD=-1.05,95%CI(-1.39,-0.71),P<0.000 01]显著短于对照组。治疗7 d后的VAS疼痛评分[SMD=-1.32,95%CI(-1.94,-0.71),P<0.0001]治疗组显著低于对照组。结论 康复新液治疗复发性阿弗他溃疡的近期疗效较好,能够缩短平均溃疡期及降低VAS疼痛评分,但尚需更多高质量的研究加以证实。对其安全性及RAU的复发性也需要进一步的关注和研究。
[Key word]
[Abstract]
Objective To evaluate the effects of Kangfuxin Liquid for treatment of recurrent aphthous ulcer. Methods Relevant literatures before April of 2019 in CNKI, Wanfang Database, VIP, CBM, CCRCT, Jiangsu Engineering Technology Literature Information Center, Pubmed and Sciencedirect were retrieved. The data that met the final inclusive criteria were meta-analyzed by Revman 5.3 software. Results A total of 13 trials were involved, including 1 353 cases. The results of Meta-analysis showed that the total effective rate of Kangfuxin Liquid (treatment group)[OR=5.45, 95%CI(3.77, 7.88), P<0.000 01), was significantly higher than that of watermelon frost and/or gargle solution (control group) for the treatment of recurrent aphthous ulcer. The average ulcer period of treatment group[SMD=-1.05, 95%CI(-1.39, -0.71), P<0.000 01] was shorter than that of control group. The VAS pain score of treatment group[SMD=-1.32, 95%CI(-1.94, -0.71), P<0.000 1] was significantly lower than that of the control group after the treatmentment of 7 days. Conclusion Kangfuxin Liquid has better short-term efficacy in the treatment of recurrent aphthous ulcer, which can shorten the average ulcer period and reduce the VAS pain score. However, it remains to be confirmed by more high-quality research. The safety and recurrence of RAU also need further attention and research.
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[基金项目]
国家自然科学基金资助项目(81570978)