目的 探讨注射用丹参多酚酸治疗急性脑梗塞的效果及对认知功能、同型半胱氨酸（Hcy）、神经元特异性烯醇化酶（NSE）、S-100β、胶质纤维酸性蛋白（GFAP）的影响。方法 选取唐山市人民医院2017年10月-2018年10月收治的急性脑梗塞患者162例，采用随机数字表法分为两组（各81例），对照组实施常规治疗，观察者在常规治疗基础上联用注射用丹参多酚酸100 mg/次，静脉滴注，1次/d，连续治疗14 d，于治疗前后检测Hcy、NSE、S-100β和GFAP，并评定患者认知功能、神经功能，比较两组临床疗效及不良反应。结果 两组患者治疗后Hcy、NSE、S-100β、GFAP、美国国立卫生研究院卒中量表（NHISS）评分均较治疗前降低（P<0.05），简易精神状态评价量表（MMSE）评分、蒙特利尔认知评估量表（MOCA）评分较治疗前增加（P<0.05）；且观察组患者治疗后Hcy、NSE、S-100β、GFAP、NHISS评分低于对照组（P<0.05），治疗后MMSE评分、MOCA评分高于对照组（P<0.05）。观察组患者总有效率高于对照组（P<0.05）；两组不良反应比较，差异无统计学意义（P>0.05）。结论 注射用丹参多酚酸治疗急性脑梗塞的效果显著，可改善认知功能和神经功能状况，并改善Hcy、NSE、S-100β、GFAP等指征。

Objective To investigate the effect of Salvianolic Acids for Injection (SAFI) in treatment for acute cerebral infarction and its influence on cognitive function, homocysteine (Hcy), neuron specific enolase (NSE), S-100β, and glial fibrillary acidic protein (GFAP). Methods A total of 162 patients were selected in Tangshan People's Hospital from October 2017 to October 2018, who were divided into two groups by random number table method (n=81). 81 patients in the observation group received routine treatment as control group. 81 patients combined with SAFI 100 mg/time, intravenous drip, once a day, continuous treatment for 14 days. Hcy, NSE, S-100β, and GFAP were detected before and after treatment, and cognitive function and neurological function were assessed. Clinical efficacy and adverse reactions were compared between two groups. Results After the treatment, Hcy, NSE, S-100β, GFAP, and NHISS score were decreased in two groups (P<0.05). MMSE score and MOCA score were increased in two groups (P<0.05). Hcy, NSE, S-100β, GFAP, and NHISS score in observation group were lower than control group (P<0.05). MMSE score and MOCA score in observation group were higher than control group (P<0.05). Total effective rate in observation group was higher than control group (P<0.05). There were no significant differences in adverse reactions between two groups (P>0.05). Conclusion SAFI has significant effect in treatment for acute cerebral infarction, which can improve cognitive function and neurological function, and improve indicators of Hcy, NSE, S-100β, and GFAP.

河北省医学科学研究重点课题（20171288，20181217）