目的 探讨血必净注射液联合盐酸氨溴索分散片对脑卒中相关性肺炎患者炎性因子水平及预后的影响。方法 选取2016年5月-2018年5月洛阳市第三人民医院76例脑卒中相关性肺炎患者为研究对象，根据随机化原则将患者分为对照组和观察组，每组各38例。对照组患者口服盐酸氨溴索分散片，1片/次，3次/d。观察组患者在对照组的基础上将50 mL血必净注射液加入到0.9%生理盐水100 mL中静脉滴注，2次/d，两组均连续治疗2周。比较两组患者的临床疗效、治疗前后血清各炎性因子水平及预后情况。结果 治疗后，观察组患者总有效率为94.74%，显著高于对照组的78.95%（P<0.05）。治疗后，两组患者白细胞介素-6（IL-6）、白细胞介素-10（IL-10）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）及降钙素原（PCT）水平较治疗前均显著下降（P<0.05），且观察组显著低于对照组（P<0.05）。观察组患者神经功能缺损程度（NIHSS）评分、急性生理和慢性健康（APACHEⅡ）评分、改良Rankin评分及病死率均显著低于对照组（P<0.05）。结论 血必净注射液联合盐酸氨溴索分散片可有效抑制机体炎性反应，提高治疗效果，对促进脑卒中相关性肺炎患者病情康复、改善预后具有积极意义。

Objective To explore effect of Xuebijing Injection combined with Ambroxol Hydrochloride Dispersible Tablets on inflammatory factor levels and prognosis in patients with stroke-associated pneumonia. Methods Patients (76 cases) with strokeassociated pneumonia were selected as the subjects from May 2016 to May 2018 were divided into control and observation group according to randomization principles, and each group had 38 cases. Patients in the control group were treated with Ambroxol Hydrochloride Dispersible Tablets on the basis of stroke treatment, 1 tablet/time, three times daily. Patients in the observation group were treated with Xuebijing Injection on the basis of control group, 50 mL added into 0.9% saline 100 mL, twice daily. Patients in two groups were treated for 2 weeks. The clinical efficacy, serum levels of inflammatory factors and prognosis before and after treatment between two groups were compared. Results After treatment, the total effective rate of the observation group was 94.74%, which was significantly higher than 78.95% of the control group (P<0.05). After treatment, the levels of IL-6, IL-10, TNF-α, CRP, and PCT in two groups were significantly lower than those before treatment (P<0.05), and the observation group was lower than those in the control group (P<0.05). NIHSS score, APACHE II score, Rankin score, and mortality of the observation group were significantly lower than those of the control group (P<0.05). Conclusion Xuebijing Injection combined with Ambroxol Hydrochloride Dispersible Tablets can effectively inhibit the inflammatory reaction of the body, and improve the therapeutic effect. It is of positive significance to promote the recovery of patients with stroke-related pneumonia and improve the prognosis.