目的 观察艾普拉唑肠溶片联合阿莫西林胶囊治疗消化性溃疡的疗效。方法 选择2016年1月-2019年1月江苏省海门市人民医院收治的98例消化性溃疡患者，随机分为两组，每组各49例。对照组服用阿莫西林胶囊治疗，0.5 g/次，3次/d，于餐后30 min服用。观察组在对照组的基础上艾普拉唑肠溶片，10 mg/次，1次/d。两组均连续治疗4周。记录患者的临床治疗效果、HP根除率、溃疡愈合时间以及HP根除时间。并检测血清胃泌素基因和胃泌素表达水平，血清白细胞介素-17（IL-17）和一氧化氮（NO）水平。结果 治疗后，观察组的总有效率为93.88%，显著高于对照组的75.51%（P<0.05）。治疗后，观察组的HP根除率高于对照组，溃疡愈合时间和HP根除时间短于对照组（P<0.05）。两组治疗后的血清胃泌素基因以及胃泌素表达水平均降低（P<0.05），且观察组更低（P<0.05）。两组治疗后的血清IL-17和NO水平均降低（P<0.05），且观察组更低（P<0.05）。结论 艾普拉唑肠溶片联合阿莫西林胶囊治疗消化性溃疡疗效显著，能降低患者的炎症反应及血清胃泌素基因和胃泌素表达水平，值得临床推广。

Objective To observe the effect of Ilaprazole Enteric-coated Tablets combined with Amoxicillin Capsules in treatment of peptic ulcer. Methods Selected 98 cases of patients with peptic ulcer who were treated in Haimen People's Hospital from January 2016 to January 2019 were divided into two groups randomly, and each group had 49 cases. The control group was treated with Amoxicillin Capsules 30 min after meal, 0.5 g/time, three times daily. While the observation group was treated with Ilaprazole Enteric-coated Tablets on the basis of control group, 10 mg/time, once daily. Patients in two groups were treated for 4 weeks. The clinical therapeutic effect, HP eradication rate, ulcer healing time and HP eradication time were recorded. Serum gastrin gene and gastrin expression levels, serum IL-17 and NO levels were detected. Results After treatment, the total effective rate of the observation group was 93.88%, which was significantly higher than 75.51% in the control group (P<0.05). After treatment, the HP eradication rate in the observation group was significantly higher than that in the control group, and the ulcer healing time and HP eradication time in the observation group were significantly shorter than those in the control group (P<0.05). After treatment, the levels of serum gastrin gene and gastrin expression in two groups were significantly decreased (P<0.05), and the levels of gastrin expression in the observation group was significantly lower (P<0.05). After treatment, the levels of serum IL-17 and NO in two groups were significantly decreased after treatment (P<0.05), and the observation group was significantly lower (P<0.05). Conclusion Ilaprazole Enteric-coated Tablets combined withAmoxicillin Capsules in treatment of peptic ulcer has a significant effect. It can reduce the inflammatory reaction, and the levels of gastrin gene and gastrin expression. It is worthy of clinical promotion.

江苏省药学会-奥赛康临床药学基金科研项目（201519）