目的 探讨小金胶囊联合注射用醋酸亮丙瑞林微球治疗卵巢巧克力囊肿的临床效果。方法 选取2015年5月—2017年1月咸阳市第一人民医院收治的116例卵巢巧克力囊肿腹腔镜手术后患者作为研究对象，前瞻性随机分为治疗组及对照组，每组58例。对照组在术后首次月经来潮第1天皮下注射给予注射用醋酸亮丙瑞林微球。治疗组则在对照组的基础上另口服给予小金胶囊，5粒/次，2次/d。两组均连续治疗6个月，并随访1年。观察两组的临床疗效，比较两组性激素指标［雌激素（E2）、卵泡刺激素（FSH）及黄体生成素（LH）］，子宫动脉血流参数［搏动指数（PI）、收缩期峰值流速/舒张末期流速比值（S/D）及阻力指数（RI）］，卵巢巧克力囊肿标记物水平［抗子宫内膜抗体（EMAb）、基质金属蛋白酶-3（MMP-3），前列腺素F2α（PGF2α）及核因子κB（NF-κB）］，生活质量指标（生理领域、环境领域、社会关系领域及生活领域评分）和1年复发率。结果 治疗后，治疗组总有效率明显高于对照组（P<0.05）。治疗后，两组性激素指标（E2、FSH及LH），子宫动脉血流参数（PI、S/D及RI），卵巢巧克力囊肿标记物水平（EMAb、MMP-3，PGF2α及NF-κB），生活质量指标（生理领域、环境领域、社会关系领域及生活领域评分）均显著得到改善，且治疗组上述指标的改善程度均明显优于对照组（P<0.05）。随访1年，治疗组复发率明显低于对照组（P<0.05）。结论 小金胶囊联合注射用醋酸亮丙瑞林微球治疗卵巢巧克力囊肿具有较好的临床疗效，值得进行深入研究。

Objective To investigate the clinical effect of Xiaojin Capsules combined with Leuprorelin Acetate Microspheres for Injection in treatment of ovarian chocolate cyst. Methods 116 patients with ovarian chocolate cyst in Xianyang First People's Hospital from May 2015 to January. 2017 were randomly divided into control and treatment groups, 58 cases in each group. Patients in the control group were treated with Leuprorelin Acetate Microspheres for Injection on day 1 of first postoperative menstruation. Patients in the treatment group were given Xiaojin Capsules after the operation on the basis of the control group, 5 grains/time, 3 times/day, for 6 months, and were followed up for 1 year. After treatment, the clinical efficacy was evaluated, and the changes of sex hormone indicators[estrogen 2 (E₂), follicle-stimulating hormone (FSH) and luteinizing hormone (LH)], uterine artery blood flow parameters[pulsation index (PI) and systolic/diastolic peak flow velocity at the end of the velocity ratio (S/D) and resistance index (RI)], levels of ovarian chocolate cyst markers[endometrial antibody (EMAb), matrix metalloproteinases-3 (MMP-3), prostaglandin F2 alpha (PGF2 alpha) and nuclear factor kappa B (nf-kappa B)] predominate, quality of life index (physical field, environment, social relationship and life grade) and 1 year recurrence rate were compared. Results After treatment, the clinical efficacy in the treatment group was significantly higher than the control group (P<0.05). After treatment, the levels of sex hormone indicators[estrogen 2 (E₂), follicle-stimulating hormone (FSH) and luteinizing hormone (LH)], uterine artery blood flow parameters[pulsation index (PI) and systolic/diastolic peak flow velocity at the end of the velocity ratio (S/D) and resistance index (RI)], levels of ovarian chocolate cyst markers[endometrial antibody (EMAb), matrix metalloproteinases-3 (MMP-3), prostaglandin F2 alpha (PGF2 alpha) and nuclear factor kappa B (nf-kappa B)] predominate, quality of life index (physical field, environment, social relationship and life grade) in the 2 groups were significantly promoted (P<0.05), while the treatment group were significantly improved than those in the control group (P<0.05). Follow up for 1 year, the recurrence rates in the treatment group was significantly lower than the control group (P<0.05).Conclusion Xiaojin Capsules combined with Leuprorelin Acetate Microspheres for Injection in treatment of ovarian chocolate cyst has significant clinical effect in treatment of ovarian chocolate cyst, which has a certain clinical application value.

陕西省教育厅自然科学研究项目（2013JK0782）