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[摘要]
目的 观察注射用丹参多酚酸联合奥美拉唑治疗应激消化溃疡合并急性缺血性卒中临床效果。方法 选择齐齐哈尔医学院附属第一医院神经内科2017年10月-2018年8月收治的应激消化溃疡合并急性缺血性卒中住院患者60例,随机分为观察组和对照组,每组30例。对照组采用参芎葡萄糖注射液200 mL,奥美拉唑40 mg、1次/d静滴治疗,观察组丹参多酚酸0.13 g,奥美拉唑40 mg、1次/d静滴治疗,均治疗14 d。分别采用神经功能缺损评分(NIHSS)和意识水平量表(GCS)判定疗效。结果 治疗后,观察组神经功能改善的总有效率为83.3%,高于对照组的63.3%,两组比较差异有统计学意义(P<0.05);观察组意识水平改善的总有效率为80.0%,高于对照组的53.3%,两组比较差异有有统计学意义(P<0.05);观察组再出血溃疡率为6.6%,低于对照组的26.6%,两组比较差异有统计学意义(P<0.05)。结论 注射用丹参多酚酸联合奥美拉唑治疗应激消化溃疡合并急性缺血性卒中患者的神经功能和意识水平均显著改善,且再出血溃疡率降低。
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[Abstract]
Objective To observe the clinical effect of Salvianolic Acids for Injection (SAFI) combined with omeprazole on stress peptic ulcer complicated with acute ischemic stroke. Methods A total of 60 patients of stress peptic ulcer complicated with acute ischemic stroke in the Frist Affiliated Hospital of Qiqihar Medical College from October 2017 to August 2018 were selected and were randomly divided into the observation group and the control group, 30 cases in each group. The patients in the control group received intravenous drip of Shenxiong Glucose Injection 200 mL, omeprazole 40 mg, qd. The patients in the treatment group were treated with intravenous drip of SAFI 0.13 g, omeprazole 40 mg, qd. The two groups were treated for two weeks. Before and after treatment, Glasgow (GCS) and NIHSS scores were used to determine the level of consciousness. Results After treatment, the total effective rate of neurological function improvement in the treatment group was 83.3%, which was significantly higher than 63.3% in the control group (P<0.05); the total effective rate of consciousness improvement in the treatment group was 80.0%, higher than 53.3% in the control group, with significant difference between the two groups (P<0.05); the rate of rebleeding ulcer in the treatment group was 6.6%, lower than 26.6% in the control group, there was significant difference between the two groups (P<0.05). Conclusion SAFI combined with omeprazole is effective in treating stress peptic ulcer complicated with acute ischemic stroke, and the rate of re-bleeding ulcer was reduced.
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