目的 观察银杏内酯注射液治疗缺血性脑卒中的疗效，并观察银杏内酯注射液在控制相关危险因素方面的治疗特点。方法 选择缺血性脑卒中患者3 036例进行非对照、开放式、多中心临床研究，在基础治疗上使用银杏内酯注射液10 mL/次，0.9%氯化钠注射液或5%葡萄糖注射液250 mL稀释，静脉滴注，每天1次，连续使用14 d。采用美国国立卫生研究院卒中量表（NIHSS）观察神经功能缺损程度，采用改良Rankin量表观察患者日常生活能力状态（病残程度），评价临床疗效。并观察患者合并高血压病、糖尿病、高血脂症和高尿酸血症4种危险因素在神经功能、病残程度和临床疗效的差异。结果 银杏内酯注射液能明显改善患者的神经功能（P<0.01），减轻病残程度（P<0.01），临床总有效率为65.72%；其中不合并4种危险因素的脑卒中患者的临床治疗总有效率为71.9%；合并高脂血症、高尿酸血症、糖尿病脑卒中患者的临床治疗总有效率分别为74.74%、75.00%、70.05%，与不合并危险因素组临床有效率基本一致；合并高血压、3种疾病和4种疾病的临床疗效相对较差，有效率分别是63.36%、42.86%和59.42%，与其他组比较有显著性差异（P<0.01）。结论 银杏内酯注射液治疗缺血性脑卒中具有较好疗效，其在控制缺血性脑卒中患者的危险因素上具有良好的治疗特点。

Objective To observe the clinical effects of Ginkgolide Injection on ischemic stroke, and study therapeutic features of ginkgolide on controlling the risk factors.Methods A total of 3 036 patients with ischemic stroke were studied in non-controlled, open, and multi-center clinical studies. All patients were given Ginkgolide Injection with 10 mL+0.9% NS/5% GS 250 mL, once daily for 14 d. The clinical efficacy of neurological funcfiondeicitsscale and daily life state was evaluated by comparing the former NIHSS scores and modified Rankin scale score with that after given treatment, respectively. The differences in neurological function, degree of disability and clinical efficacy of patients with four different risk factors:hypertension, diabetes, hyperlipidemia, and hyperuricemia were observed.Results Ginkgolide Injection can significantly improve the neurologic function of patients (P < 0.01) and reduce the degree of disability (P < 0.01), and the total clinical efficiency was 65.72%.The clinical efficiency of stroke patients without four kind of risk factors was 71.9%. The clinical efficiency of stroke patients with hyperlipidemia, hyperuricemia, and diabetic was 74.74%, 75%, and 70.05%, respectively, and was basically in line with that of stroke patients without any risk factor. The clinical efficiency of stroke patients with hypertension, three and four kinds of disease was 63.36%, 42.86%, and 59.42%, respectively, and was significantly different with that of stroke patients without any risk factor (P < 0.01).Conclusion Ginkgolide Injection has a positive effect on ischemic stroke with good therapeutic features on controlling the risk factors.