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[摘要]
目的 探讨多奈哌齐联用奥氮平治疗脑血管病伴发精神行为症状的疗效。方法 2012年2月-2017年2月选择在咸阳市核工业二一五医院诊治的脑血管病伴发精神行为症状患者84例作为研究对象,根据入院顺序,按照随机信封抽签原则分为观察组与对照组各42例,对照组给予奥氮平10 mg,1次/d,观察组在对照组治疗的基础上给予多奈哌齐5 mg,均治疗观察4周。比较两组临床疗效、简易精神状态检查量表(MMSE)评分、认知功能状况及不良反应。结果 观察组的总有效率是95.2%,显著高于对照组的81.0%(P<0.05)。治疗后观察组的反应时是(487.24±30.23)s,对照组的是(545.30±31.49)s;治疗后观察组的正确数是(285.30±11.44)个,对照组的是(251.44±13.09)个;治疗后观察组的漏划数是(18.49±6.46)个,对照组的是(38.28±4.56)个;两组对比差异明显(P<0.05)。与治疗前相比,治疗后观察组与对照组治疗的MMSE评分显著提高(P<0.05);与治疗后对照组的MMSE评分相比,观察组的显著提高(P<0.05)。观察组的不良反应发生率31.0%,对照组不良反应发生率28.6%,两组不良反应程度均较轻微,对比无明显差异。结论 多奈哌齐联用奥氮平治疗脑血管病伴发精神行为症状能改善患者的认知功能与神经心理学状况,安全性比较好,从而提高治疗效果。
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[Abstract]
Objective To evaluate the curative effect of donepezil combined with olanzapine in the treatment of cerebrovascular disease with mental symptoms. Methods From February 2012 to February 2017, 84 patients of cerebrovascular disease with mental symptoms in our hospital for diagnosis and treatment were selected as the research object, all of the patients were divided into observation group and control group with 42 cases in each group accorded to the order of admission, in accordance with the principle of random draw envelope. The control group was given olanzapine treatment, the observation group was given donepezil combined with olanzapine in the treatment. Results The total effective rate of the observation group and the control group was 95.2% and 81.0% respectively, and the total effective rate of the observation group was significantly higher than that of the control group (P<0.05). The reaction time, the correct number and the number of drain strokes in observation group after treatment were (487.24±30.23) s, (285.30±11.44) and (18.49±6.46), the control group were (545.30±31.49) s, (251.44±13.09) and (38.28±4.56), that compared between the two groups were significant differences (P<0.05). The MMSE scores of the observation group and the control group after treatment were significantly higher than that before treatment (P<0.05), and the scores of MMSE in the observation group after treatment was significantly higher than those in the control group (P<0.05). The incidence of adverse reactions was 31% in the observation group and 28.6% in the control group. The adverse reactions in the two groups were mild and there was no significant difference between the two groups. Conclusion Donepezil combined with olanzapine in the treatment of cerebrovascular disease with mental symptoms can improve cognitive function and neuropsychological status with good security, thereby enhance the therapeutic effect.
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