[关键词]
[摘要]
目的 探讨复方樟柳碱联合康柏西普玻璃体腔给药治疗湿性老年性黄斑变性(AMD)的效果。方法 研究时间为2014年4月-2017年10月,采用随机抽样与回顾性研究方法,选择在渭南市中心医院眼科就诊的湿性AMD患者144例作为研究对象,根据治疗方法的不同分为研究组与对照组各72例,对照组给予康柏西普玻璃体腔给药治疗,研究组在对照组治疗的基础上联合复方樟柳碱治疗,两组均治疗14 d,记录两组预后与视力变化情况。结果 治疗后研究组与对照组的总有效率分别为97.2%和84.7%,研究组显著高于对照组,差异有统计学意义(P<0.05)。两组经过治疗后视力都显著提高,同组治疗前后比较差异有统计学意义(P<0.05);其中研究组的视力提高比对照组更加显著,差异有统计学意义(P<0.05)。治疗后研究组荧光素渗漏消失40例,减少30例,无变化2例;对照组分别为25例、30例与17例,对比有显著差异(P<0.05)。结论 复方樟柳碱联合康柏西普玻璃体腔给药治疗湿性AMD能提高视力,减少荧光渗漏的发生,提高治疗效果,值得在临床上推广应用。
[Key word]
[Abstract]
Objective To investigate the effects of conbercept vitreous cavity administration combined with compound anisodine in the treatment of wet age-related macular degeneration (AMD). Methods The study time was from April 2014 to October 2017, Used the random sampling and retrospective research methods, 144 cases of patients with wet AMD were selected in our hospital and were divided into study group and control group with 72 cases in each groups accorded to the different treatment methods. The control group was given conbercept vitreous cavity administration treatment, and the study group were given the conbercept vitreous cavity administration combined with compound anisodine treatment, the visual acuity and prognosis in the two groups were recorded. Results The total effective rate of the study group and the control group after treatment was 97.2% and 84.7% respectively, and the study group was significantly higher than the control group (P<0.05). The visual acuity of the two groups after treatment were improved significantly, and the improvement of visual acuity in the study group weremore significant than that of the control group, and compared the difference were statistically significantly (P<0.05). After treatment, there were 40 cases of fluorescein leakage disappeared in the study group, 30 cases were reduced, 2 cases did not change. The control group was 25 cases, 30 cases and 17 cases, respectively that compared were significantly difference (P<0.05). Conclusion The conbercept vitreous cavity administration combined with compound anisodine in the treatment of wet AMD can improve vision, reduce the occurrence of fluorescence leakage, improve the therapeutic effect, which it is worthy of clinical application.
[中图分类号]
[基金项目]