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[摘要]
目的 研究卡马西平联合盐酸洛美利嗪胶囊治疗偏头痛的临床治疗效果。方法 选择2012年2月-2016年12月在新疆医科大学第六附属医院进行诊治的偏头痛患者70例,随机分为观察组与对照组,每组各35例。对照组患者于早晚饭后口服盐酸洛美利嗪胶囊5 mg,每天2次,观察组在此基础上于餐后联合口服卡马西平,初始剂量为每次0.1 g,每天2次,第2天后每隔1天增加0.1~0.2 g,待疼痛缓解后,采用维持剂量0.4~0.8 g/d进行治疗,两组均治疗3个月。比较两组的临床治疗效果,观察两组治疗前后的24 h内头痛缓解维持时间和头痛发作频率,采用VAS对患者疼痛程度进行评估,并随访1个月观察患者的复发情况。结果 观察组有效率为94.29%(33/35),明显高于对照组的77.14%(27/35),差异有统计学意义(P<0.05)。两组治疗后的24 h内头痛缓解维持时间均明显增加(P<0.05),VAS评分以及头痛发作频率均明显降低(P<0.05);与对照组相比,观察组上述观察指标改善程度较好,组间差异有统计学意义(P<0.05)。经过1个月的随访发现,对照组复发4例,观察组复发1例,观察组的复发率为2.86%(1/35),明显低于对照组的11.43%(4/35),差异有统计学意义(P<0.05)。观察组的不良反应发生率为17.14%(6/35),与对照组的11.43%(4/35)相比无明显差异。结论 卡马西平联合盐酸洛美利嗪胶囊对偏头痛具有显著的临床效果,可以有效降低头痛发作频率,缓解头痛程度,缩短发作时间,且复发率较低,安全性高,值得应用推广。
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[Abstract]
Objective To investigate the clinical effect oflomerizine hydrochloride capsules combined with carbamazepine in the treatment of migraine.Methods Selected 70 cases of patients with migraine who were treated in our hospital from February 2012 to December 2016, divided into two groups randomly, 35 cases in observation group, 35cases in control group. Patients in the control group were treated with Lomerizine Hydrochloride Capsules 5 mg orally 2 times a day after morning and evening. The observation group in combination with oral carbamazepine, the initial measurement for 0.1 g each time, 2 times a day, second days every 1 days increased 0.1-0.2 g, pain relief to be maintained by measurement of 0.4-0.8 g/d treatment. The clinical treatment effects were compared between the two groups, two groups were observed before and after treatment within 24 h headache remission duration and frequency of headache, to evaluate the degree of pain in patients with VAS, and followed up for 1months to observe the recurrence rate of patients.Results After treatment, the effective rate of the observation group was 94.29% (33/35), significantly higher than that of the control group 77.14% (27/35) (P< 0.05); within 24 h after treatment, headache relief, duration of maintenance were significantly increased (P< 0.05), and VAS scores and frequency of headache attacks were significantly lower (P< 0.05), compared with the control group, the observation group improved the above indexes better (P< 0.05); after 1 months of follow-up, 4 cases were found in the control group and 1 cases in the observation group. The recurrence rate of the observation group was 2.86% (1/35), which was significantly lower than that of the control group 11.43% (4/35) (P< 0.05);the incidence of adverse reactions in the observation group was 17.14% (6/35), has no significant difference with 11.43% (4/35) in the control group.Conclusion Lomerizine Hydrochloride Capsules combined with carbamazepine has significant clinical effect on migraine, which can effectively reduce the frequency of headache, alleviate the headache, shorten the onset time, and have a low recurrence rate and high safety.
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