目的 探讨咪达唑仑联合地西泮治疗小儿惊厥持续状态的疗效及安全性。方法 将西安市儿童医院自2014年1 月-2016年12月收治的小儿惊厥持续状态患儿66例作为研究对象，根据入院时间随机分为两组，对照组32例患儿给予地西泮，研究组34例患儿在对照组基础上给予咪达唑仑，观察两组患儿的治疗效果和安全性。结果 研究组患者临床有效率为94.12%，对照组为75.00%，组间比较差异有统计学意义（P<0.05）。研究组药物起效时间和惊厥控制时间均少于对照组，差异具有统计学意义（P<0.05）。研究组患儿的呼吸道分泌物增多例数较对照组，但可耐受。结论 咪达唑仑联合地西泮治疗小儿惊厥持续状态，起效快，安全有效，可在临床范围内推广使用。

Objective To investigate the therapeutic effect and safety of midazolam on the persistence of pediatric patients. Methods 66 cases of pediatric convulsions from January 2014 to December 2016 were enrolled in this study. According into the admission time, 34 cases children in the study group were treated with midazepam on the base of control group, the control group of 32 children with diazepam, two groups of children with therapeutic effect and safety were observed. Results The clinical effective rate was 94.12% in the study group and 75.00% in the control group. The difference between two groups was statistically significant (P<0.05). The time of onset and the time of convulsion were lower than those of the control group, the difference was statistically significant (P<0.05); the respiratory secretions increase of the study group was more than the control group, while who were tolerated. Conclusion Midazolam continuous intravenous infusion treatment of convulsion status, rapid onset, safe and effective, which can be used in the clinical scope.