目的 观察沙利度胺联合柳氮磺吡啶治疗强直性脊柱炎对病情活动及功能活动的效果。方法 选择2013年1月-2015年12月在昆山市第一人民医院确诊的强直性脊柱炎患者60例作为研究对象，根据随机数字表法分为观察组与对照组各30例，对照组给予柳氮磺吡啶肠溶片治疗，观察组在此基础上加用沙利度胺片治疗，两组都治疗观察3个月。结果 所有患者都完成治疗，无严重不良反应发生，观察组与对照组的总有效率分别为96.7%和83.3%，观察组的总有效率明显高于对照组，差异有统计学意义（P<0.05）。观察组与对照组治疗后的脊柱活动度分别为（51.34±11.94）°和（43.14±9.34）°，都明显高于治疗前的（30.42±13.98）°和（30.45±12.87）°，同组治疗前后比较差异有统计学意义（P<0.05）；观察组治疗后的脊柱活动度明显高于对照组，差异有统计学意义（P<0.05）。观察组与对照组治疗后的腰椎骨密度T值分别为-0.59±0.32和-0.89±0.13，都明显高于治疗前的-1.21±0.11和1.29±0.15，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后观察组的腰椎骨密度也明显高于对照组，差异有统计学意义（P<0.05）。结论 沙利度胺联合柳氮磺吡啶治疗强直性脊柱炎有很好的应用安全性，能促进腰椎骨密度的恢复，改善脊柱活动度，从而提高治疗疗效。

Objective To observe the effects of sulfasalazine enteric coated tablets combined with thalidomide in the treatment of ankylosing spondylitis disease activity and functional activities. Methods From January 2013 to December 2015, 60 ankylosing spondylitis patients in our hospital were selected as the research object and were randomly divided into observation group and control group with 30 patients in each group. the control group was given sulfasalazine treatment, the observation group was received thalidomide enteric coated tablets treatment based on the treatment in control group, two groups were treated for 3 months. Results All patients were completed and treatment, and there were no serious adverse reactions occurred during the treatment, the total effective rates of observation group and control group were 96.7% and 83.3% respectively, the total effective rate of observation group was significantly higher than that of control group (P<0.05). The spinal mobility in the observation group and the control group after treatment were (51.34 ±11.94)° and (43.14 ±9.34)°, that were significantly higher than before treatment of (30.42 ±13.98)° and (30.45 ±12.87)° (P<0.05), and the observation group after treatment of spinal activity was significantly higher than the control group (P<0.05). The lumbar bone mineral density of the observation group and control group were -0.59 ±0.32 and -0.89 ±0.13, which were significantly higher than before treatment (-1.21 ±0.11 and 1.29 ±0.15), while after treatment the observation group was higher than the control group (P<0.05). Conclusion Sulfasalazine enteric coated tablets in the treatment of ankylosing spondylitis has good safety, it can promote the bone mineral density of lumbar spine recovery, improve the spinal mobility, so as to improve the curative effect.