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[摘要]
目的 对比泮托拉唑与奥美拉唑治疗消化道溃疡出血的疗效。方法 选取80例消化道溃疡患者,随机分为两组,观察组静脉滴注泮托拉唑,对照组静脉滴注奥美拉唑,两组均治疗7 d。观察并记录两组患者治疗后的疗效、治疗前后胃液pH值、出血时间、住院时间及出血量和治疗期间不良反应情况,评价奥美拉唑与泮托拉唑治疗消化道溃疡出血的疗效及安全性。结果 观察组有效率92.7%,对照组有效率89.7%,两组治疗有效率无明显差异;但观察组显效率(85.4%)明显高于对照组(56.4%),差异有统计学意义(P<0.05)。治疗前两组胃液呈酸性,pH值相比无统计学差异,治疗后两组胃液pH有所提高,观察组胃液pH值高于对照组,差异有统计学意义(P<0.05)。观察组患者住院时间、止血时间均短于对照组,差异有统计学意义(P<0.05);出血量明显少于对照组,差异有统计学意义(P<0.05)。治疗期间,观察组患者不良反应明显少于对照组,差异有统计学意义(P<0.05)。结论 泮托拉唑与奥美拉唑均适用于消化道溃疡出血的治疗,但泮托拉唑抗酸和止血效果更好,药物安全性更高,值得临床推广使用。
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[Abstract]
Objective To discuss the efficacy of omeprazole and pantoprazole in treatment of peptic ulcer hemorrhage. Methods 80 patients with peptic ulcer hemorrhage were selected, they were divided into two groups randomly. The observation group(41 cases) was given pantoprazole by intravenous drip. The control group(39 cases) was given omeprazole by intravenous drip. The efficacy and safety of omeprazole and pantoprazole in treatment of peptic ulcer hemorrhage was evaluated by efficacy, pH before and after treatment, bleeding time, hospitalization and bleeding volume, and adverse reaction during treatment. Results The effective rate was 92.7% in the observation group and 89.7% in the control group. There was no statistical significance on effective rate between two groups. But the excellent rate of observation group was higher than that of the control group(P<0.05). Before treatment, the gastric acid was acidic. There were no statistical significance on pH value between two groups. After treatment, the pH value was increased in two groups. The pH value of observation group was higher than that of the control group(P<0.05). The hospitalization, hemostasis time and bleeding volume was shorter than that of the control group(P<0.05). During treatment, the patients given pantoprazole had less adverse reaction(P<0.05). Conclusion Pantoprazole and omeprazole are suitable for treating peptic ulcer hemorrhage. But the antacid and hemostatic effect of pantoprazole was better with high safety. It was worthy of clinical application.
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