绞股蓝皂苷为绞股蓝的主要活性成分，属于达玛烷型四环三萜，其在药材中含量高、容易获得，主要生物活性体现在抗肿瘤、降血糖、降血脂、心脑血管保护等方面。绞股蓝皂苷易受酸、碱、酶的影响而降解，水解后不仅脱去糖生成次级苷，而且苷元的结构也会发生变化。查阅近年来国内外文献并进行归纳总结，综述绞股蓝皂苷水解产物化学结构与药理作用的研究进展，为寻找结构新颖、活性更强的先导化合物提供参考。

The biologically active constituents in Gynostemma pentaphyllum are dammarane-type glycosides, called gypenosides. They are believed to be the highest contents of this herb, easy to obtain, and mainly active in anti-tumor, controlling the blood glucose, lipid-lowering, cardiovascular protection, etc. The saponins may change into sub-glucoside after hydrolysis, for the internal acetal glucoside structure is vulnerable to acid, alkali, and enzyme degradation. Through searching the literatures in recent years, this paper summarized the chemical constituents in the hydrolyzed products of gypenosides, for providing references to discover novel and more active lead compounds.

国家自然科学基金青年科学基金（81602983），辽宁省自然科学基金优秀人才培养项目（2015020698）