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[摘要]
目的 探讨甲巯咪唑联合131I治疗甲状腺功能亢进的疗效及安全性。方法 收取2012年6月-2015年6月之间西安交通大学附属三二0一医院收治的甲状腺功能亢进患者83例作为研究对象,根据随机数字表法将其分为观察组42例及对照组41例,观察组予以甲巯咪唑联合131I治疗,对照组予以丙硫氧嘧啶联合131I治疗。对两组患者临床疗效、用药前后甲状腺血清学指标、不良反应以及复发率进行考察与对比。结果 观察组患者临床治疗总有效率为95.24%,远远高于对照组的70.73%,差异有统计学意义(P<0.05)。治疗后两组患者血清促甲状腺素(TSH)较治疗前升高,三碘甲腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素受体抗体(TRAb)以及甲状腺过氧化物酶抗体(TPOAb)均较治疗前下降;且观察组TSH明显高于对照组,T3、T4、FT3、FT4明显低于对照组,差异有统计学意义(P<0.05)。观察组患者总不良反应发生率(14.29%)显著低于对照组(46.34%),差异有统计学意义(P<0.05)。观察组复发率(4.76%)明显低于对照组(26.83%),差异有统计学意义(P<0.05)。结论 甲巯咪唑联合131I治疗甲状腺功能亢进患者疗效及安全性好,值得临床推广应用。
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[Abstract]
Objective To explore the clinical effect and safety of methimazole combined with 131I in treatment of hyperthyroidism.Methods Patients (83 cases) with hyperthyroidism accepted in Xi'an Jiaotong University Affiliated San Er Ling Yi Hospital from June 2012 to June 2015 were selected and divided into observation group with 42 cases and control group with 41 cases. Patients in observation group were given methimazole combined with 131I, and patients in control group were given PTU combined with 131I. Then the clinical effect, thyroid gland serological indexes, adverse reations, and reoccurrence rates of two groups were observed and compared.Results The total clinical efficacy of observation group was 95.24%, which was obviously higher than 70.73% of control group with statistically significance (P<0.05). TSH was getting higher after treatment of two groups, and T3, T4, FT3, FT4, TRAb, and TPOAb were getting lower after treatment of two groups. And TSH in the observation group was significantly higher than that in the control group, T3, T4, FT3, and FT4 were significantly lower than those in the control group (P<0.05). The adverse reaction rate of observation group (14.29%) was obviously lower than that of control group (46.34%) with statistically significance (P<0.05). The reoccurrence rate of observation group (4.76%) was obviously lower than that of control group (26.83%) with statistically significance (P<0.05).Conclusion Methimazole combined with 131I has good effect and safety in treatment of hyperthyroidism, which is worth of clinical application.
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