目的 探讨克林霉素注射液联合保妇康栓对慢性宫颈炎伴高危型人乳头瘤病毒（hr-HPV）感染患者的疗效分析。方法 选取100例慢性宫颈炎伴hr-HPV感染患者，随机分为两组，对照组（49例）给予保妇康栓，观察组（51例）给予克林霉素注射液联合保妇康栓，观察并记录两组疗效、HPV转阴率、治疗前后炎性因子水平、治疗期间两组不良反应情况，评价保妇康栓联合克林霉素注射液对慢性宫颈炎伴hr-HPV感染患者的治疗效果。结果 治疗后，观察组有效率为92.1%，对照组有效率为75.5%，观察组有效率明显高于对照组（P<0.05）；治疗后，观察组HPV转阴率为90.2%，对照组为59.2%，观察组治疗后HPV转阴率明显高于对照组（P<0.05）。治疗前，两组超敏C反应蛋白（hs-CRP）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）无统计学差异；治疗后，两组hs-CRP、IL-6、TNF-α均明显下降，且观察组hs-CRP、IL-6、TNF-α水平明显低于对照组（P<0.05）；治疗期间，两组不良反应率比较，差异无统计学意义。结论 克林霉素注射液联合保妇康栓对慢性宫颈炎伴hr-HPV具有良好的治疗作用，抗HPV效果好，能显著控制炎症因子，且安全性好，值得临床推广使用。

Objective To discuss the efficacy of Baofukang combined with clindamycin injection in treatment of chronic cervicitis patients with high-risk human papilloma virus infection (hr-HPV).Methods Totally 100 patients who had chronic cervicitis with hr-HPV were selected and divided into two groups randomly. The patients in control group (49 cases) were given Baofukang. The patients in observation group (51 cases) were given Baofukang combined with clindamycin injection. The efficacy of Baofukang combined with clindamycin injection in treatment of chronic cervicitis patients with hr-HPV was evaluated by efficacy, HPV negative rate, inflammatory factors before and after treatment and adverse reaction during treatment.Results After treatment, the effective rate of observation group was 92.1%, and the effective rate of control group was 75.5%, the effective rate of observation group was higher than that of control group (P<0.05). After treatment, the HPV negative rate in observation group was 90.2%, the control group was 59.2%, the HPV negative rate of observation group was higher than that of control group (P<0.05). Before treatment, there was no statistical significance on hs-CRP, IL-6, and TNF-α between two groups. After treatment, the hs-CRP, IL-6, and TNF-α were decreased in two groups (P<0.05). The hs-CRP, IL-6, and TNF-α of observation group were lower than those of control group (P<0.05). There was no statistical significance on adverse reaction between two groups.Conclusion Baofukang combined with clindamycin injection had a good therapeutic effect on chronic cervicitis with hr-HPV. It could inhibit HPV and inflammatory factors well. It was safe and worthy of clinical use.