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[摘要]
女贞子及其提取物具有降血糖、调血脂、抗肥胖作用,其活性成分主要有齐墩果酸、熊果酸、红景天苷、酪醇、女贞子苷等单体化合物。其通过保护β细胞和刺激胰岛素表达和分泌,以及对抗胰岛素抵抗产生拟胰岛素样作用,从而刺激各种组织细胞利用葡萄糖和脂质,促进骨、骨骼肌和棕色脂肪生长,平衡体内脂质、葡萄糖和能量的代谢,产生降低血糖、调血脂、抗肥胖的药理作用。
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[Abstract]
Ligustri Lucidi Fructus and its extracts have hypoglycemia, lipidemic regulation, and antiobesity effects. Oleanolic acid, ursolic acid, salidroside, tyrosol, and nuezhenide are major active constituents from Ligustri Lucidi Fructus. By inducing protection of pancreatic β cell, and stimulating secretion and expression of insulin, and by antagonizing insulin resistance, and imitating insulin-like action, they stimulate utilization of glucose and lipids in various tissues and cells, and improve the homeostasis of metabolism of glucose, lipids and energy, to produce the pharmacologic effects for decreasing hyperglycemia and hyperlipemia, and antiobesity.
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