小檗碱是黄连的主要成分,属于异喹啉类生物碱,具有调血脂、抗血栓形成、降血糖、抗氧化、抗炎、抑制血管平滑肌细胞增殖、保护血管内皮细胞和促血管内皮舒张因子释放等多种作用,且能从多个环节抑制动脉粥样硬化的形成与发展。综述研究近年来有关小檗碱对动脉粥样硬化作用机制的相关文献,发现其作用机制主要包括调控炎症因子相关基因的表达、抗氧化应激、减少脂质合成、改善血管内膜细胞等几方面,从而为小檗碱临床应用及研发新的天然药物提供理论基础。

Berberine is the main component of Chinese materia medica Coptidis Rhizoma, which belongs to the category of alkaloids, with the effects of regulating blood fat, anti-thrombosis, reducing blood sugar, anti-oxidation, anti-inflammation, inhibiting tube smooth muscle cell proliferation, and protecting vascular endothelial cells, and the effect of a variety of factors, such as release of angiogenic endothelial diastolic, and can inhibit the formation and development of atherosclerosis from multiple aspects. The advances in research in recent years of berberine on the mechanism of the atherosclerosis related literature, found that the mechanism mainly included several aspects such as regulation of inflammatory cytokine related gene expression, oxidative stress, reduced lipid synthesis, improved endothelial cell, etc., which provided theoretical basis and clinical application of berberine for the development of new natural drugs.

创新药物研究开发技术平台建设(2012ZX09303-010-001)